2型糖尿病患者的餐后血脂与动脉粥样硬化的研究进展  

Research progress of postprandial lipids and atherosclerosis in patients with type 2 diabetes mellitus

作　　者：钟玉华 林铭旭 师柔 蒿自睿[3] 李桂平 ZHONG Yuhua;LIN Mingxu;SHI Rou;HAO Zirui;LI Guiping(The First Clinical College of Medicine,Guangdong Medical University,Zhanjiang 524023,Guangdong,China;Department of Endocrinology,Huizhou Central People's Hospital,Huizhou 516001,Guangdong,China;Department of Endocrinology,the Third People's Hospital of Huizhou,Huizhou 516002,Guangdong,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524023 [2]惠州市中心人民医院内分泌科,广东惠州516001 [3]惠州市第三人民医院内分泌科,广东惠州516002

出　　处：《检验医学》2024年第8期815-819,共5页Laboratory Medicine

基　　金：惠州市科技计划项目(2022CZ010420)。

摘　　要：2型糖尿病(T2DM)患者血管病变的病理生理学机制复杂,易出现动脉粥样硬化,导致血管腔狭窄,最终引发冠状动脉粥样硬化性心脏病、缺血性卒中等严重心脑血管疾病和糖尿病足、截肢等严重并发症。血脂异常是动脉粥样硬化的高危因素,过去多以空腹血脂来代表个体的血脂状态。然而,餐后血脂才是1 d内占主导地位的脂类状态,是全天最真实的状态。餐后高脂血症是糖尿病脂代谢异常的重要特征,并可能促进动脉粥样硬化。文章对T2DM患者血脂的变化特点、餐后血脂与动脉粥样硬化的关系等方面的研究进展进行综述。The pathophysiological mechanism of vascular disease in type 2 diabetes mellitus(T2DM)is complex,and atherosclerosis is prone to occur,leading to vascular stenosis,and eventually leading to coronary atherosclerotic heart disease,ischemic stroke and other serious cardiovascular and cerebrovascular diseases,as well as diabetic foot,amputations and other serious complications.Dyslipidemia is a high risk factor for atherosclerosis.In the past,fasting lipids were used to represent the status of individual lipids.However,postprandial lipids are the dominant lipid state within 1 d and are the most true state throughout the day.Postprandial hyperlipemia is an important characteristic of abnormal lipid metabolism in diabetes mellitus and may promote atherosclerosis.This review focuses on the changes of blood lipids in T2DM patients and the relationship between postprandial blood lipids and atherosclerosis.

关 键 词：餐后血脂 2型糖尿病 动脉粥样硬化 

分 类 号：R446.1[医药卫生—诊断学]