基于天然骨仿生的骨组织工程设计综述  

Review on biomimetic design of bone tissue engineering based on natural bone

作　　者：高建朋 朱正国[1] 李明[1] 刘建恒[1] GAO Jianpeng;ZHU Zhengguo;LI Ming;LIU Jianheng(Department of Orthopedics,the Fourth Medical Center,Chinese PLA General Hospital,National Orthopedics and Sports Rehabilitation Clinical Research Center,Beijing 100853,China)

机构地区：[1]解放军总医院第四医学中心骨科,国家骨科与运动康复临床医学研究中心,北京100853

出　　处：《解放军医学院学报》2024年第7期789-793,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(82372401);北京市自然科学基金项目(L202033)。

摘　　要：骨组织工程可以在骨缺损治疗前期提供匹配缺损的支架,引导新生骨形成,并提供活性因子、种子细胞等促进骨组织再生,在骨修复中有广泛的应用。良好的骨组织工程设计至关重要。受天然骨组织自身特性的启发,骨组织工程支架与仿生科学之间的联系越来越密切,成分、结构和功能仿生成为制备骨组织工程支架的重要方法。本文根据天然骨组织固有性质,对不同仿生方式,如成分仿生、结构仿生及功能仿生进行简要介绍,并对其在骨组织工程中的应用进行综述,旨在为骨组织工程的设计提供新的思路与方法。Bone tissue engineering(BTE)has a wide range of applications in bone repair as it provides the scaffold to match the defect in the early stage of the treatment of bone defects,guiding the ingrowth of new tissues and providing active factors and cells to promote bone regeneration.A good design of bone tissue engineering is crucial.Inspired by the properties of natural bone,the connection between BTE and bionic science is getting closer and closer,making biomimetics of composition,structure and function an attractive method for the preparation of BTE.Based on the properties of natural bone,different bionic approaches,such as compositional bionic,structural bionic and functional bionic,are briefly introduced,and their applications in BTE are reviewed,intending to provide new thoughts and methods for the design of BTE.

关 键 词：骨组织工程 骨缺损 成分仿生 结构仿生 功能仿生 

分 类 号：R318.08[医药卫生—生物医学工程]