基于数据挖掘探析陈焕朝教授治疗乳腺癌用药经验  

Analysis of Professor Chen Huanchao’s Experience in Treating Breast Cancer on the Basis of Data Mining

作　　者：李嫚[1] 王绚璇[1] 陈焕朝[1] 张鹏[2] LI Man;WANG Xuanxuan;CHEN Huanchao;ZHANG Peng(Department of Integrated Traditional Chinese and Western Medicine,Hubei Cancer Hospital,Wuhan 430079,China;Department of Pharmacy,Hubei Provincial Hospital of TCM,Wuhan 430061,China)

机构地区：[1]湖北省肿瘤医院中西医结合科,武汉430079 [2]湖北省中医院药事部,武汉430061

出　　处：《肿瘤防治研究》2024年第8期678-683,共6页Cancer Research on Prevention and Treatment

基　　金：国家中医药管理局第七批全国名老中医药专家学术经验继承项目[国中医药人教函(2022)76号];全国中药特色技术传承人才培训项目[国中医药人教函(2023)96号]。

摘　　要：目的运用数据挖掘技术探析湖北省名老中医陈焕朝教授治疗乳腺癌用药经验。方法收集陈焕朝教授治疗乳腺癌病案,经筛选、整理后录入患者首诊处方。运用Excel 2019对药物频次、功效频次和性味归经进行分析,采用SPSS Modeler 18.0软件对药物进行关联规则分析及网络展示,利用SPSS 27.0软件对高频药物进行聚类分析,总结用药规律。结果共纳入处方185首,涉及中药180味,筛选出高频药物29味。药性以平、寒、温为主,药味以甘、苦、辛为主,归经多归肝经、肺经、脾经、肾经,药物功效以补虚药、清热药、利水渗湿药为主。关联规则分析得到20组药对,聚类分析主要呈现2个类别。结论陈焕朝教授认为乳腺癌属本虚标实,应从“虚、瘀、痰、毒”论治,扶正祛邪兼施,标本兼治,重视疏肝理气,调补脾肾,兼以活血化瘀、化痰消积、清热解毒,为中医药治疗乳腺癌提供思路。Objective To analyze the experience of Professor Chen Huanchao,a famous TCM doctor in Hubei Province,in treating breast cancer by data mining technology.Methods The medical records of Professor Chen Huanchao’s treatment of breast cancer were collected,and the first prescription of each patient was recorded after screening and sorting.MS Excel 2019 was used to analyze drug frequency,efficacy frequency,and the meridian distribution,and SPSS Modeler 18.0 software was adopted for association rule analysis and network display of drugs.SPSS 27.0 was employed for clustering analysis of high-frequency drugs to summarize medication patterns.Results A total of 185 prescriptions involving 180 traditional Chinese medicines were included,and 29 high-frequency drugs were screened.The medicinal properties were mainly neutral,cold,and warm,and the medicinal flavors were mainly sweet,bitter,and pungent.The meridians were liver,lung,spleen,and kidney meridians.The medicinal effects primarily included tonifying deficiency,clearing heat,and promoting diuresis and dampness.The association rule analysis showed 20 groups of drug pairs,and the cluster analysis mainly revealed two categories.Conclusion Professor Chen Huanchao believes that breast cancer involves root deficiency and excessive symptoms and should be treated from the perspective of“deficiency,blood stasis,phlegm,and toxin.”Genuine-Qi should be strengthened,and Evil-Qi should be eliminated.The symptoms and root causes of this disease should be treated simultaneously while soothing the liver and qi,tonifying the spleen and kidney,promoting blood circulation,removing phlegm and preventing its accumulation,and clearing heat and detoxify.This work provides ideas for the treatment of breast cancer with traditional Chinese medicine.

关 键 词：乳腺癌 用药经验 数据挖掘 陈焕朝 

分 类 号：R273[医药卫生—中西医结合] R737.9[医药卫生—中医肿瘤科]