铌改性医用温敏性聚乳酸基聚氨酯弹性体  

Niobium modified medical temperature-sensitive polylactic acid based polyurethane elastomer

作　　者：曹亚奇 胡素佩[2] 孙俪文 汪心彦 余海斌[3] CAO Yaqi;HU Supei;SUN Liwen;WANG Xinyan;YU Haibin(Zhejiang Wanli University,Ningbo 315100,China;The Second Hospital of Ningbo,Ningbo 315099,China;Ningbo Institute of Materials Technology&Engineering,Chinese Academy of Sciences,Ningbo 315201,China)

机构地区：[1]浙江万里学院生物与环境学院,浙江宁波315100 [2]宁波市第二医院,浙江宁波315099 [3]中国科学院宁波材料技术与工程研究所,浙江宁波315201

出　　处：《工程塑料应用》2024年第8期64-71,共8页Engineering Plastics Application

基　　金：宁波市科学技术局科技创新2025重大专项(2020Z087)。

摘　　要：聚乳酸基聚氨酯弹性体(PLA-TPU)具有良好的力学性能、耐磨性、生物相容性和生物可降解性,近年来已成为体内植入材料的研究热点。温敏性PLA-TPU还可应用于特殊的体内植入材料,进一步促进PLA-TPU在体内植入材料领域的发展。然而,PLA-TPU在不添加显影剂的情况下不具备显影性能,无法保证其在体内的安全性。为了促进PLA-TPU在生物材料领域的更好发展,对PLA-TPU进行了显影改性研究。铌(Nb)是一种生物相容性良好的组织工程材料,并且具有良好的显影性。基于此,使用Nb作为显影剂对温敏性PLA-TPU进行了改性,以传统显影剂硫酸钡(BaSO_(4))和新一代显影剂氯氧化铋(BiOCl)作为对照组,通过熔融共混制备了一系列PLA-TPU显影复合材料,研究了不同显影剂对PLA-TPU的显影性和温敏性的影响。结果表明,Nb综合了BaSO_(4)和BiOCl的优点,对PLA-TPU具有可忽略不计的温敏性影响和较好的显影改性效果,是一种医用温敏性材料良好的显影改性剂。同时,用质量分数40%Nb制备的PLA-TPU/40Nb显影复合材料在显影性、温敏性和体内柔软性方面表现俱佳。PLA-TPU/40Nb的显影性是PLA-TPU的1.65倍,具有良好的显影性;玻璃化转变温度为30.54℃,具有体内温敏性;从室温到体温的模量下降率为74%,符合良好温敏性的要求;在体温下的储能模量为117 MPa,柔软性较好。因此,PLA-TPU/40Nb具有作为人体植入类温敏性医用导管材料的巨大潜力。Polylactic acid based polyurethane(PLA-TPU)has become a research hotspot for in vivo implant materials due to its good mechanical properties,abrasion resistance,biocompatibility and biodegradability.The temperature sensitive PLA-TPU can also be applied to special vivo implant materials,which will further promote the development of PLA-TPU in the field of in vivo implant materials.However,PLA-TPU does not have developability to ensure the safety in vivo without the addition of developer.In order to promote the better development performance of PLA-TPU in the field of biomaterials,the development modification of PLA-TPU was investigated.Niobium(Nb)is a biocompatible material for tissue engineering and has good development properties.Based on this,Nb as the developer was used to modify temperature sensitive PLA-TPU compared to the traditional developer barium sulfate(BaSO_(4))and the new generation developer bismuth chloride oxide(BiOCl).The effects of different developers on the development performance and temperature sensitivity of PLA-TPU were studied.The results show that Nb combines the advantages of BaSO_(4)and BiOCl,and has slight effect on the temperature sensitivity and better development modification effect on PLA-TPU,which is a good development modifier for medical thermosensitive materials.At the same time,PLA-TPU developed composites prepared with 40%Nb exhibit excellent development properties,temperature sensitivity and softness in vivo.PLA-TPU/40Nb has good development property,which is 1.65 times that of PLA-TPU.Its glass transition temperature was 30.54℃,indicating its temperature sensitivity in vivo.The modulus of from room temperature to the temperature of the falling rate was 74%,in line with the requirements of good temperature sensitive.Its storage modulus at body temperature is 117 MPa,and its flexibility is good.Therefore,PLA-TPU/40Nb has great potential as a temperature-sensitive medical catheter material for human implantation.

关 键 词：铌 聚氨酯 聚乳酸 X射线成像 温敏性 复合材料 生物材料 

分 类 号：TQ327.8[化学工程—合成树脂塑料工业]