金属多酚复合物修饰蒙脱土基pH响应性纳米农药载体的制备及药物缓释机制  

Preparation of montmorillonite-based pH-responsive nanopesticide carrier modified by metal polyphenol complex and drug sustained release mechanism

作　　者：满丽 陈铧耀[2,3] 周红军[2,3] 郝丽 周新华[2,3] MAN Li;CHEN Huayao;ZHOU Hongjun;HAO Li;ZHOU Xinhua(College of Light Industry and Food Technology,Zhongkai University of Agriculture and Enginering,Cuangzhou 510225,China;College of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Enginering,Cuangzhou 510225,China;Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,China)

机构地区：[1]仲恺农业工程学院轻工食品学院,广东广州510225 [2]仲恺农业工程学院化学化工学院,广东广州510225 [3]仲恺农业工程学院广东省普通高校农业绿色精细化学品重点实验室,广东广州510225

出　　处：《仲恺农业工程学院学报》2024年第3期1-10,共10页Journal of Zhongkai University of Agriculture and Engineering

基　　金：广东省自然科学基金(2022A1515010258);广东省重点领域研发计划项目(2023B02028002).

摘　　要：为了提高农药的利用率,减少药物损失并使其在特定环境下缓慢释放,采用钛酸四丁酯(Tetrabutyltitanate,Ti)柱撑蒙脱土(Montmorillonite,Mt),利用金属离子螯合单宁酸(Tannin,Ta)修饰蒙脱土并用于负载阿维菌素(Avermectin,AVM),得到了具有pH响应的药物缓释体系(AVM@Fe-Ta-TiPMt/AVM@Cu-Ta-TiPMt).利用热重分析仪、傅里叶变换红外光谱、X射线衍射等仪器对样品结构进行表征,所制备的AVM@Fe-Ta-TiPMt和AVM@Cu-Ta-TiPMt的水合粒径为345.72 nm和570.88 nm,Zate电位分别为-38.09 mV和-32.88 mV.研究了样品在不同的pH条件下对AVM缓释性能的影响,结果表明,AVM@Fe-Ta-TiPMt中的AVM在中性条件下累计释放率(85%)高于AVM@TiPMt(77%),AVM@Cu-Ta-TiPMt的AVM在中性条件下的累计释放率(51.4%)均低于其在pH值为4和9条件下的累计释放率.表明这种具有pH响应性纳米缓释体系能使药物在特定的环境下释放.In order to increase the utilization of pesticides,reduce losses and enable its slowly release in a specific environment.In this study,Tetrabutyltitanate(Ti)and Tannin(Ta)were used to modify Montmorillonite(Mt)to load Avermectin(AVM).The obtained pH responsive drug sustained release system was named AVM@Fe-Ta-TiPMt and [e-mail] structure of the clay samples were characterized by Thermogravimetric analyzer(TGA),Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),etc.Thenanopartcials with an average of 345.72 nm of AVM@Fe-Ta-TiPMt and 570.88 nm of AVM@Cu-Ta-TiPMt and the Zate potential was-38.09 mV and-32.88 mV.The effect of different metal ion-chelated tannic acid-modified samples on the slow-release performance of AVM at different pH conditions was investigated.The results showed that the cumulative release rate of AVM in AVM@Fe-Ta-TiPMt(85%)under neutral conditions was higher than that in AVM@TiPMt(77%),and the cumulative release rate of AVM in AVM@Cu-Ta-TiPMt(51.4%)under neutral conditions was lower than that of its cumulative release rate at both pH 4 and 9.Indicating that this pH-responsive nano sustained release system enables the release of pesticide in specific environments.

关 键 词：蒙脱土 药物缓释 单宁酸 金属多酚 纳米黏土 

分 类 号：O69[理学—化学]