头针联合言语听觉反馈认知训练对脑外伤后认知障碍患者认知功能、脑血流和血清神经细胞因子的影响  

Effect of Scalp Acupuncture Combined with Speech Auditory Feedback Cognitive Training on Cognitive Function,Cerebral Blood Flow,and Serum Neurocytokines in Patients with Cognitive Impairment after Brain Injury

作　　者：卢晓霞 张炜[2] 方舟[3] 邓林 付莹颖 LU Xiao-xia;ZHANG Wei;FANG Zhou;DENG Lin;FU Ying-ying(Department of Training and Rehabilitation,Western Theater Command Air Force Hospital of the Chinese People's Liberation Army,Chengdu,Sichuan,610000,China;Department of Neurosurgery,Western Theater Command Air Force Hospital of the Chinese People's Liberation Army,Chengdu,Sichuan,610000,China;Department of Traditional Chinese Medicine,Western Theater Command Air Force Hospital of the Chinese People's Liberation Army,Chengdu,Sichuan,610000,China;Department of Rehabilitation,Sichuan Friendship Hospital,Chengdu,Sichuan,610000,China)

机构地区：[1]中国人民解放军西部战区空军医院训练康复科,四川成都610000 [2]中国人民解放军西部战区空军医院神经外科,四川成都610000 [3]中国人民解放军西部战区空军医院中医科,四川成都610000 [4]四川友谊医院康复科,四川成都610000

出　　处：《现代生物医学进展》2024年第15期2925-2928,共4页Progress in Modern Biomedicine

基　　金：四川省医学会青年创新科研项目(Q17007)。

摘　　要：目的:观察头针联合言语听觉反馈认知训练对脑外伤后认知障碍患者认知功能、脑血流和血清神经细胞因子的影响。方法:采用随机数字表法将我院2021年8月~2023年2月期间接收的102例脑外伤后认知障碍患者分为对照组(n=51,接受言语听觉反馈认知训练)和实验组(n=51,在对照组的基础上接受头针干预)。对比两组干预前后的蒙特利尔认知评估量表(MoCA)、脑血流指标[平均血流速度(Vm)、局部脑血流量(r CBF)、局部脑血容量(r CBV)]和血清神经细胞因子[S100β、神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)、神经生长因子(NGF)],同时观察两组干预期间不良反应发生情况。结果:两组干预后视空间与执行功能、命名、注意、语言、抽象、延迟回忆、定向各维度评分和总分均升高,且实验组高于对照组(P<0.05)。两组干预后Vm、r CBF、r CBV均升高,且实验组高于对照组(P<0.05)。两组干预后S100β、NSE、NGF均降低,且实验组低于对照组;BDNF升高,且实验组高于对照组(P<0.05)。干预期间,两组不良反应发生率对比无统计学差异(P>0.05)。结论:头针联合言语听觉反馈认知训练可有效改善脑外伤后认知障碍患者认知功能,且安全性较好,可能与改善脑血流和血清神经细胞因子水平有关。Objective: To observe the effects of scalp acupuncture combined with speech auditory feedback cognitive training oncognitive function, cerebral blood flow, and serum neurocytokines in patients with cognitive impairment after brain injury. Methods: 102patients with cognitive impairment after brain injury admitted to our hospital from August 2021 to February 2023 were divided intocontrol group (n=51, received speech auditory feedback cognitive training) and experimental group (n=51, received scalp acupunctureintervention on the basis of the control group) by random number table method. Compared Montreal cognitive assessment scale (MoCA),cerebral blood flow indicators [mean blood flow velocity (Vm), local cerebral blood flow (rCBF), local cerebral blood volume (rCBV)],and serum neurocytokines [S100β, Neuron specific enolase (NSE), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF)]between two groups before and after intervention, and the occurrence of adverse reactions during the intervention period were observedin both groups. Results: After intervention, the scores and total scores of visual space and executive function, naming, attention, language,abstraction, delayed recall, and orientation in both groups increased, and the experimental group was higher than the control group (P<0.05). After intervention, Vm, rCBF, and rCBV increased in both groups, and the experimental group was higher than the control group(P<0.05). After intervention, S100 β, NSE and NGF groups in both decreased, and the experimental group was lower than the controlgroup;BDNF increased, and the experimental group was higher than the control group (P<0.05). During the intervention period, therewas no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of scalp acupuncture and verbal auditory feedback cognitive training can effectively improve cognitive function in patientswith cognitive impairment after brain injury, and the safety is good, w

关 键 词：头针 言语听觉反馈认知训练 脑外伤 认知障碍 认知功能 脑血流 神经细胞因子 

分 类 号：R651.1[医药卫生—外科学]