腱糖蛋白C、三酰甘油葡萄糖指数、血清骨硬化蛋白在维持性血液透析合并心血管事件中的临床意义分析  

Clinical Significance Analysis of Tendon Glycoprotein C,Triglyceride Glucose Index,and Serum Osteosclerosis Protein in Maintenance Hemodialysis Complicated with Cardiovascular Events

作　　者：崔云霞 张玲[1] 刘虹颖[1] 王凯月 李艳婷 娄宏君[1] CUI Yun-xia;ZHANG Ling;LIU Hong-ying;WANG Kai-yue;LI Yan-ting;LOU Hong-jun(Department of Laboratory Medicine,The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang,150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院检验科,黑龙江哈尔滨150040

出　　处：《现代生物医学进展》2024年第15期2945-2949,共5页Progress in Modern Biomedicine

基　　金：黑龙江省中医药科研基金项目(ZHY2023-134)。

摘　　要：目的:探讨腱糖蛋白C(TN-C)、三酰甘油葡萄糖指数(TyG)、血清骨硬化蛋白(SOST)在维持性血液透析合并心血管事件中的诊断意义及预后预测价值。方法:选取我院2020年1月到2023年1月收治的80例维持性血液透析合并心血管事件患者作为研究对象,将其分为观察组,另选取同期收治的80例维持性血液透析未合并心血管事件的患者作为对照组。对比两组患者TN-C、TyG、SOST表达水平,建立受试者工作特征(ROC)曲线分析TN-C、TyG、SOST对血液透析合并心血管事件的诊断效能。对所有患者进行随访,记录随访过程中由心血管事件导致的死亡情况,将死亡患者分为预后不良组(n=25),其余患者分为预后良好组(n=55),对比其临床相关资料,采取logistics回归模型分析TN-C、TyG、SOST对维持性血液透析合并心血管事件的预后预测价值。结果:两组患者TN-C、TyG、SOST水平对比差异显著,观察组明显高于对照组(P<0.05);TN-C+SOST+TyG三者联合NSE对血液透析合并心血管事件的诊断曲线下面积为0.897,且灵敏度与特异度明显高于单一指标(P<0.05);预后良好组与预后不良组性别、BMI、合并基础疾病对比无明显差异(P>0.05),预后良好组与预后不良组年龄、透析时间、饮酒史、吸烟史、TN-C、TyG、SOST水平对比差异显著(P<0.05);logistic回归分析结果显示:年龄、TN-C、TyG、SOST为维持性血液透析合并心血管事件预后独立预测因素(P<0.05)。结论:TN-C、TyG、SOST在维持性血液透析合并心血管事件的诊断及预后预测中具有重要价值,且三者联合可提升维持性血液透析合并心血管事件的诊断效能。Objective:To explore the diagnostic significance and prognostic value of Tendon glycoprotein C(TN-C),Triacylglycerol glucose index(TyG),and serum osteosclerosis protein(SOST)in maintenance hemodialysis with cardiovascular events.Method:80 patients with maintenance hemodialysis complicated with cardiovascular events admitted to our hospital from January 2020 to January 2023 were selected as the study subjects and divided into an observation group.In addition,80 patients without cardiovascular events admitted to maintenance hemodialysis during the same period were selected as the control group.Compare the expression levels of TN-C,TyG,and SOST between two groups of patients,and establish receiver operating characteristic(ROC)curves to analyze the diagnostic efficacy of TN-C,TyG,and SOST for cardiovascular events in hemodialysis patients.Follow up all patients,record the mortality caused by cardiovascular events during the follow-up process,and divide the deceased patients into a poor prognosis group(n=25)and the remaining patients into a good prognosis group(n=55).Compare their clinical related data and use logistic regression models to analyze the predictive value of TN-C,TyG,and SOST for the prognosis of maintenance hemodialysis combined with cardiovascular events.Result:There was a significant difference in TN-C,TyG,and SOST levels between the two groups of patients,with the observation group significantly higher than the control group(P<0.05);The area under the diagnostic curve of the three combined NSE for hemodialysis combined with cardiovascular events is 0.897,and the sensitivity and specificity are significantly higher than single indicators(P<0.05);There was no significant difference in gender,BMI,and comorbidities between the group with good prognosis and the group with poor prognosis(P>0.05).However,there were significant differences in age,dialysis time,alcohol consumption history,smoking history,TN-C,TyG,and SOST levels between the group with good prognosis and the group with poor prognosis (P<0.05);T

关 键 词：腱糖蛋白C 三酰甘油葡萄糖指数 血清骨硬化蛋白 维持性血液透析 心血管事件 

分 类 号：R459.5[医药卫生—治疗学]