双嘧达莫联合大剂量丙种球蛋白、阿司匹林治疗小儿川崎病的效果及对心肌损伤标志物、凝血状态的影响  

Effect of dipyridamole combined with high-dose gamma globulin and aspirin in the treatment of Kawasaki disease in children and its influences on myocardial injury markers and coagulation status

作　　者：史敏 赵叶 SHI Min;ZHAO Ye(Pediatrics Department,Xi'an Gaoxin Hospital,Xi'an 710077,China)

机构地区：[1]西安高新医院儿科,陕西西安710077

出　　处：《临床医学研究与实践》2024年第24期38-41,共4页Clinical Research and Practice

摘　　要：目的探讨双嘧达莫联合大剂量丙种球蛋白、阿司匹林治疗小儿川崎病的效果及对心肌损伤标志物、凝血状态的影响。方法选取2020年1月至2023年1月我院收治的100例川崎病患儿,按照随机数字表法将其分为对照组和观察组,各50例。对照组采用大剂量丙种球蛋白联合阿司匹林治疗,观察组在对照组基础上加用双嘧达莫治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。观察组的发热缓解时间、躯干红斑消退时间、黏膜弥漫性充血消失时间、颈淋巴结肿胀缓解时间及住院时间均短于对照组(P<0.05)。治疗后,两组的氨基末端脑钠肽前体(NT-proBNP)、血管紧张素Ⅱ(AngⅡ)水平比较,差异无统计学意义(P>0.05);治疗后,两组的肌钙蛋白T(cTnT)水平均降低,且观察组低于对照组(P<0.05)。治疗后,两组的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)均延长,纤维蛋白原(FIB)水平均降低,且观察组优于对照组(P<0.05)。观察组的冠状动脉损伤总发生率为8.00%,低于对照组的24.00%(P<0.05)。结论双嘧达莫联合大剂量丙种球蛋白、阿司匹林治疗川崎病患儿的效果显著,可有效改善临床症状,减轻心肌损伤程度,调节凝血功能,降低冠状动脉损伤发生率。Objective To explore the effect of dipyridamole combined with high-dose gamma globulin and aspirin in the treatment of Kawasaki disease in children and its influences on myocardial injury markers and coagulation status.Methods A total of 100 children with Kawasaki disease admitted in our hospital from January 2020 to January 2023 were selected and divided into control group and observation group according to the random number table method,with 50 cases in each group.The control group was treated with high-dose gamma globulin combined with aspirin,and the observation group was treated with dipyridamole on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The fever relief time,trunk erythema regression time,mucosal diffuse congestion disappearance time,cervical lymph node swelling relief time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).After treatment,there were no significant differences in the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP)and angiotensinⅡ(AngⅡ)between the two groups(P>0.05);after treatment,the level of cardiac troponin T(cTnT)in the two groups decreased,and that in the observation group was lower than the control group(P<0.05).After treatment,the activated partial thromboplastin time(APTT)and prothrombin time(PT)of the two groups prolonged,the fibrinogen(FIB)level decreased,and those in the observation group were better than the control group(P<0.05).The total incidence of coronary artery injury in the observation group was 8.00%,which was lower than 24.00%in the control group(P<0.05).Conclusion Dipyridamole combined with high-dose gamma globulin and aspirin in the treatment of children with Kawasaki disease has significant effect,which can effectively improve clinical symptoms,reduce the degree of myocardial injury,regulate coagulation function,and decline the inc

关 键 词：双嘧达莫 丙种球蛋白 阿司匹林 小儿 川崎病 

分 类 号：R725.4[医药卫生—儿科]