加味结肠舒联合酪酸梭菌肠球菌三联活菌片治疗老年肝郁肾虚型慢传输型便秘的临床研究  

Treatment of Elderly Patients with Chronic Slow Transit Constipation of Liver-stagnation Kidney-deficiency Type with Modified Jiechangshu Combined with Clostridium Butyricum And Enterococcus Faecium Triple Viable Capsules

作　　者：李甜 田茂生[2] 王海鑫 徐文聪 梅君蔓 高记华[2] LI Tian;TIAN Mao-sheng;WANG Hai-xin;XU Wen-cong;MEI Jun-man;GAO Ji-hua(Hebei University of Chinese Medicine,Shijiazhuang,050091,China;Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang,050013,China)

机构地区：[1]河北中医药大学,石家庄050091 [2]河北省中医院,石家庄050013

出　　处：《河北中医药学报》2024年第4期13-18,共6页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北中医学院科研能力提升重点项目:No.KTZ2019033。

摘　　要：目的:研究加味结肠舒方联合酪酸梭菌肠球菌三联活菌片治疗老年肝郁肾虚型慢传输型便秘(slow transit constipation,STC)的临床疗效。方法:选取2021年12月至2023年6月就诊于河北省中医院的老年肝郁肾虚型STC患者100例,随机分为2组,每组各50例。其中观察组采用酪酸梭菌肠球菌三联活菌片联合加味结肠舒,对照组采用酪酸梭菌肠球菌三联活菌片,均进行为期2个月的治疗,分别比较2组患者治疗前后便秘中医证候积分、结肠传输实验结果、肠神经递质5-羟色胺(5-HT)的水平和肠道菌群水平以及复发情况。结果:观察组患者治疗后的有效率为96%,对照组患者治疗后的有效率为76%。治疗后观察组患者中医证候积分、结肠传输试验残留标志物数量均低于对照组(P<0.05),血清5-HT水平提高(P<0.05),肠道菌群的水平中乳酸杆菌、双歧杆菌等数量增加而肠杆菌数量减少(P<0.05)。结论:加味结肠舒联合酪酸梭菌肠球菌三联活菌片对于治疗老年肝郁肾虚型STC的临床疗效优于单用益生菌。Objective:To investigate the clinical efficacy of the modified Jiechangshu formula combined with Clostridium Butyricum and Enterococcus Faecium Triple Viable Capsules in treating elderly patients with slow transit constipation(STC) of liver-stagnation kidney-deficiency type.Methods:A total of 100 elderly patients with STC of liver-stagnation kidney-deficiency type who visited Hebei Provincial Hospital of Traditional Chinese Medicine from December 2021 to June 2023 were selected and randomly divided into two groups,with 50 patients in each group.The observation group received a combination therapy of Clostridium Butyricum and Enterococcus Faecium Triple Viable Capsules and modified Jiechangshu formula,while the control group received only Clostridium Butyricum and Enterococcus Faecium Triple Viable Capsules.Both groups underwent a 2-month treatment period.The Chinese medicine syndrome scores for constipation,results of colonic transit test,levels of intestinal neurotransmitter(5-HT),gut microbiota levels,and recurrence rates were compared between the two groups before and after treatment.Results:The effective rate in the observation group after treatment was 96%,while that in the control group was 76%.After treatment,the Chinese medicine syndrome scores and the number of residual markers in the colonic transit test were lower in the observation group compared to the control group(P<0.05);The serum level of 5-HT increased(P<0.05);Among the gut microbiota levels,the numbers of lactobacillus and bifidobacterium increased,while the number of enterobacteria decreased(P<0.05).Conclusion:The combination therapy of modified Jiechangshu formula and Clostridium Butyricum and Enterococcus Faecium Triple Viable Capsules is more effective than probiotics alone in treating elderly patients with STC of liver stagnation and kidney deficiency type.

关 键 词：慢传输型便秘 加味结肠舒 酪酸梭菌肠球菌三联活菌片 血清5-HT 肠道菌群 

分 类 号：R256[医药卫生—中医内科学]