调补脾肾中药复方治疗原发性骨质疏松症临床研究  

Treatment of Primary Osteoporosis with Traditional Chinese Medicine Compound for Regulating Spleen and Kidney

作　　者：张玉[1] 孙玉凤[1] 高志红[1] 焦丽静 赵会琪 ZHANG Yu;SUN Yu-feng;ZHAO Zhi-hong;JIAO Li-jing;ZHAO Hui-qi(The Second Hospital of Hebei Medical University,Shijiazhuang,050000,China;Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang,050001,China)

机构地区：[1]河北医科大学第二医院,石家庄050000 [2]石家庄市中医院,石家庄050051

出　　处：《河北中医药学报》2024年第4期19-22,44,共5页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省中医药管理局科研计划项目:No.2024043。

摘　　要：目的:观察调补脾肾中药复方治疗原发性骨质疏松症(primary osteoporosis,POP)的临床疗效。方法:POP患者共计60例,采用随机数字表法随机分为对照组(30例)和治疗组(30例)。对照组治疗方法为常规综合治疗,治疗组治疗方法为在对照组的基础上加用调补脾肾中药复方。比较2组患者的骨密度、血清碱性磷酸酶(ALP)、血红蛋白(Hb)、白蛋白(ALB)、血钙(Ca)、血磷(P)及临床疗效。结果:治疗组总有效率高于对照组(P<0.05)。治疗后,2组的ALP水平均降低,治疗组低于对照组(P<0.05),Hb、ALB水平及骨密度均提高,三个指标相比较治疗组高于对照组(P<0.05)。结论:POP用调补脾肾中药复方治疗效果明确,能有效调节ALP、Hb、ALB水平,提高骨密度。Objective:To observe the clinical efficacy of a traditional Chinese medicine(TCM) compound for regulating spleen and kidney in the treatment of primary osteoporosis(POP).Methods:A total of 60 patients with POP were randomly divided into a control group(30 patients) and a treatment group(30 patients).The control group received conventional comprehensive treatment,while the treatment group received the same treatment as the control group with the addition of the TCM compound for regulating spleen and kidney.The bone mineral density(BMD),serum alkaline phosphatase(ALP),hemoglobin(Hb),albumin(ALB),serum calcium(Ca),serum phosphorus(P),and clinical efficacy were compared between the two groups.Results:The total effective rate in the treatment group was higher than that in the control group(P<0.05).After treatment,the serum ALP levels decreased in both groups,with the treatment group showing a lower level than the control group(P<0.05);Hb,ALB and BMD all increased in both groups,with the treatment group demonstrating higher levels in these three indicators compared to the control group(P<0.05).Conclusion:The TCM compound for regulating spleen and kidney exhibits a clear therapeutic effect in the treatment of POP,effectively regulating serum ALP,Hb,and ALB levels,and improving BMD.

关 键 词：原发性骨质疏松症 中药疗法 疗效 

分 类 号：R259[医药卫生—中西医结合]