黄芪生脉饮联合常规西药治疗气阴两虚型老年肺炎临床研究  

Clinical Study on Huangqi Shengmai Decoction Combined with Conventional Western Medicine for Senile Pneumonia of Qi-Yin Deficiency Type

作　　者：韩利峰 张娟 付子龙 HAN Lifeng;ZHANG Juan;FU Zilong(Department of Respiratory Medicine,Chun'an County First People's Hospital,Chun'an Zhejiang 311700,China;Department of Nephrology,Chun'an County First People's Hospital,Chun'an Zhejiang 311700,China)

机构地区：[1]淳安县第一人民医院呼吸内科,浙江淳安311700 [2]淳安县第一人民医院肾内科,浙江淳安311700

出　　处：《新中医》2024年第16期47-51,共5页New Chinese Medicine

摘　　要：目的:观察黄芪生脉饮联合常规西药治疗气阴两虚型老年肺炎的临床疗效。方法:将86例气阴两虚型老年肺炎患者按随机数字表法分为观察组与对照组各43例,观察组最终完成试验42例(剔除1例),对照组41例(剔除2例)。对照组给予退热、抗感染、化痰止咳等常规西药治疗,观察组在对照组基础上联合黄芪生脉饮治疗,比较2组临床疗效、中医证候评分、血清炎症因子[C-反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)、白细胞介素-8 (IL-8)]、T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))及体液免疫指标[免疫球蛋白A (IgA)、免疫球蛋白M (IgM)]水平。结果:观察组总有效率95.24%,对照组为80.49%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医主症、次症评分及总分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。治疗后,2组CRP、TNF-α、IL-8水平均较治疗前降低(P<0.05),且观察组上述3项指标均低于对照组(P<0.05)。治疗后,2组CD4^(+)、CD4^(+)/CD8^(+)、IgA、IgM水平均较治疗前升高(P<0.05),且观察组CD4^(+)、CD4^(+)/CD8^(+)、IgA、IgM水平均高于对照组(P<0.05);2组CD8^(+)水平均较治疗前降低(P<0.05),且观察组CD8^(+)水平低于对照组(P<0.05)。结论:黄芪生脉饮联合常规西药治疗气阴两虚型老年肺炎效果显著,可缓解患者中医证候,减轻炎症反应,改善机体免疫功能。Objective:To observe the clinical effect of Huangqi Shengmai Decoction combined with conventional western medicine for senile pneumonia of qi-yin deficiency type.Methods:A total of 86 cases of senile patients with pneumonia of qi-yin deficiency type were divided into the observation group and the control group according to the random number table method,with 43 cases in each group;finally,42 cases in the observation group(one case was excluded)and 41 cases in the control group(two cases were excluded)completed the trial.The control group was treated with conventional western medicine for the abatement of fever,anti-infection,and resolving phlegm and relieving cough,and the observation group was additionally treated with Huangqi Shengmai Decoction based on the treatment of the control group.Clinical effects,traditional Chinese medicine(TCM)syndrome scores,and the levels of serum inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and interleukin-8(IL-8)],T lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),and humoral immune indicators[immunoglobulin A(IgA)and immunoglobulin M(IgM)]were compared between the two groups.Results:After treatment,the total effective rate was 95.24%in the observation group and 80.49%in the control group,the difference being significant(P<0.05).After treatment,the scores of main symptoms and secondary symptoms as well as the total TCM scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CRP,TNF-α,and IL-8 in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of the three indicators in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CD4^(+),CD4^(+)/CD8^(+),IgA,and IgM in the two groups were increased when compared with those before treatment(P<0.05),and the levels of CD4^(+),CD4^(+)/CD8^(+),IgA,and IgM

关 键 词：老年肺炎 气阴两虚 黄芪生脉饮 炎症因子 免疫功能 

分 类 号：R563.1[医药卫生—呼吸系统]