补肾强骨除痹汤联合西药治疗膝骨关节炎疗效观察及对血清抗炎因子的影响  

Observation on Curative Effect of Bushen Qianggu Chubi Decoction Combined with Western Medicine on Knee Osteoarthritis and Its Effect on Serum Anti-Inflammatory Factors

作　　者：章学文 张建华[1] 陈海燕 薛中杰[2] 刘尧 ZHANG Xuewen;ZHANG Jianhua;CHEN Haiyan;XUE Zhongjie;LIU Yao(Huzhou Third People's Hospital,Huzhou Zhejiang 313000,China;The First People's Hospital of Huzhou,Huzhou Zhejiang 313000,China)

机构地区：[1]湖州市第三人民医院,浙江湖州313000 [2]湖州市第一人民医院,浙江湖州313000

出　　处：《新中医》2024年第16期66-70,共5页New Chinese Medicine

摘　　要：目的:观察补肾强骨除痹汤联合西药治疗膝骨关节炎(KOA)的疗效及对血清抗炎因子的影响。方法:选取106例KOA患者,按随机数字表法分为对照组及治疗组各53例。对照组采用常规西药治疗,治疗组在对照组基础上联合补肾强骨除痹汤治疗。比较2组临床疗效及不良反应发生情况,比较2组治疗前后中医证候评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、膝关节Lysholm功能、生活质量测评量表(SF-36)评分、血清抗炎因子[血清转化生长因子-β1 (TGF-β1)、白细胞介素-13 (IL-13)]水平的变化。结果:治疗组临床疗效总有效率为96.23%,对照组为83.02%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组关节疼痛、腰膝酸软、脉细无力中医证候评分均较治疗前下降,治疗组上述3项中医证候评分均低于对照组(P<0.05)。治疗后,2组WOMAC评分均较治疗前下降(P<0.05),Lysholm、SF-36评分均较治疗前升高(P<0.05);治疗组WOMAC评分低于对照组(P<0.05), Lysholm、 SF-36评分均高于对照组(P<0.05)。治疗后,2组TGF-β1、IL-13水平均较治疗前下降(P<0.05),治疗组TGF-β1、IL-13水平均低于对照组(P<0.05)。对照组不良反应发生率为11.32%,治疗组不良反应发生率为7.55%,2组比较,差异无统计学意义(P>0.05)。结论:补肾强骨除痹汤联合西药治疗KOA临床疗效较好,能有效缓解患者症状和体征,提高膝关节功能及生活质量,减轻炎症反应,安全性高。Objective:To observe the curative effect of Bushen Qianggu Chubi Decoction(BQCD)combined with western medicine on knee osteoarthritis(KOA)and its effect on serum anti-inflammatory factors.Methods:A total of 106 KOA patients were selected and divided into the control group and the treatment group according to the random number table method,with 53 cases in each group.The control group was treated with routine western medicine,and the treatment group was additionally treated with BQCD based on the treatment of the control group.The clinical effects and incidence of adverse reactions,and the changes in traditional Chinese medicine(TCM)syndrome scores,scores of Western Ontario and McMaster University Arthritis Index(WOMAC),Lysholm Knee Scoring Scale and Short Form of Quality of Life(SF-36)Scale,and levels of serum anti-inflammatory factors[serum transforming growth factor-β1(TGF-β1)and interleukin-13(IL-13)]before and after treatment were compared between the two groups.Results:The total clinical effective rate was 96.23%in the treatment group and 83.02%in the control group,the difference being significant(P<0.05).After treatment,the TCM syndrome scores of joints pain,soreness of the waist and knees and thin and weak pulse in both groups were reduced when compared with those before treatment,and the above three scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the WOMAC scores in both groups were decreased when compared with those before treatment(P<0.05),and the scores of Lysholm and SF-36 were elevated when compared with those before treatment(P<0.05);the WOMAC score in the treatment group was lower than that in the control group(P<0.05),and the scores of Lysholm and SF-36 were higher than those in the control group(P<0.05).After treatment,the levels of TGF-β1 and IL-13 in the two groups were down-regulated when compared with those before treatment(P<0.05),and the above two levels in the treatment group were lower than those in the control group(P<0.05).The incidenc

关 键 词：膝骨关节炎 肝肾亏虚型 补肾强骨除痹汤 膝关节功能 抗炎因子 

分 类 号：R684.3[医药卫生—骨科学]