Chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease:Correlations with blood eosinophil level  

慢性阻塞性肺疾病急性加重期患者胸部CT定量参数与血嗜酸性粒细胞水平的相关性

作　　者：YANG Lu SHENG Yadan YANG Kai HE Liyu GU Huihui SUN Guoqing CHEN Weiting ZHU Bingjie CHEN Yanrong JIN Chenwang 杨璐;盛亚丹;杨凯;何立宇;谷慧慧;孙国庆;陈伟婷;朱冰洁;陈雁蓉;金晨望(西安交通大学第一附属医院医学影像科,陕西西安710061;陕西中医药大学医学技术学院,陕西咸阳712046;安康市人民医院医学影像科,陕西安康725000)

机构地区：[1]Department of Medical Imaging,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China [2]School of Medical Technology,Shaanxi University of Chinese Medicine,Xianyang 712046,China [3]Department of Medical Imaging,Ankang People's Hospital,Ankang 725000,China

出　　处：《中国医学影像技术》2024年第8期1189-1193,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家卫生健康委能力建设和继续教育中心放射影像数据库建设项目(YXFSC2022JJSJ002)。

摘　　要：Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 162 AECOPD patients with elevated eosinophils were retrospectively analyzed.The patients were divided into low EOS group(n=105)and high EOS group(n=57)according to the absolute counting of blood EOS.The quantitative CT parameters,including the number of whole lung bronchi and the volume of blood vessels,low-attenuation area percentage(LAA%)of whole lung,of left/right lung and each lobe of lung,as well as the luminal diameter(LD),wall thickness(WT),wall area(WA)and WA percentage of total bronchial cross-section(WA%)of grade 3 to 8 bronchi were compared between groups.Spearman correlations were performed to analyze the correlations of quantitative CT parameters with blood EOS level.Results LAA%of the whole lung,of the left/right lung and each lobe of lung,as well as of the upper lobe of right lung LD grade 4,middle lobe of right lung WT grade 5,upper lobe of right lung WA grade 4,middle lobe of right lung WA grade 5 and lower lobe of left lung WA grade 3 in low EOS group were all higher than those in high EOS group(all P<0.05).Except for the upper lobe of right lung LD grade 4,the above quantitative CT indexes being significant different between groups were all weakly and negatively correlated with blood EOS level(r=-0.335 to-0.164,all P<0.05).Conclusion Chest CT quantitative parameters of AECOPD patients were correlated with blood EOS level,among which LAA%,a part of WT and WA were all weakly negatively correlated with blood EOS level.目的观察慢性阻塞性肺疾病急性加重期(AECOPD)患者胸部CT定量参数与血嗜酸性粒细胞(EOS)水平的相关性。方法回顾性分析162例EOS增多型AECOPD患者胸部CT,根据血EOS绝对计数将其分为低EOS组(n=105)及高EOS组(n=57);比较组间CT定量参数,包括全肺支气管数量及血管体积,全肺、左/右肺及各肺叶低密度衰减区容积占全肺容积百分比(LAA%),以及第3~8级支气管管腔内径(LD)、管壁厚度(WT)、管壁面积(WA)及WA占支气管断面总面积百分比(WA%);采用Spearman相关分析观察CT定量参数与血EOS水平的相关性。结果低EOS组全肺、左/右肺及各肺叶LAA%,以及右肺上叶LD第4级、右肺中叶WT第5级、右肺上叶WA第4级、右肺中叶WA第5级及左肺下叶WA第3级均高于高EOS组(P均<0.05)。除右肺上叶LD第4级外,上述组间差异有统计学意义的CT定量参数均与血EOS水平呈弱负相关(r=-0.335~-0.164,P均<0.05)。结论AECOPD患者胸部CT定量参数与血EOS水平相关;LAA%及部分WT、WA均与血EOS水平呈弱负相关。

关 键 词：pulmonary disease chronic obstructive EOSINOPHILS tomography X-ray computed 

分 类 号：R563[医药卫生—呼吸系统] R814.42[医药卫生—内科学]