新加黄龙汤治疗急性有机磷农药中毒的临床疗效  

Clinical Effect of Xinjia Huanglong Decoction on Acute Organophosphorus Pesticide Poisoning

作　　者：马云飞 刘俊明 李振 李培恒 王可 MA Yunfei;LIU Junming;LI Zhen;LI Peiheng;WANG Ke(Bozhou Branch of Anhui Provincial Hospital of Traditional Chinese Medicine,Bozhou Traditional Chinese Medicine Hospital,Anhui Bozhou 236800,China)

机构地区：[1]安徽省中医院亳州分院,亳州市中医院,安徽亳州236800

出　　处：《中医药临床杂志》2024年第8期1604-1607,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：2021年第2批亳州市重点研发计划(自筹经费)项目(bzzc2021057);2021年度安徽中医药大学临床科研项目(2021LCBZ18)。

摘　　要：目的:观察新加黄龙汤鼻饲治疗急性有机磷农药中毒(AOPP)患者的临床疗效。方法:选择亳州市中医院2022年1月—2023年10月收治的急性有机磷农药中毒(AOPP)患者60例,随机分为对照组30例,治疗组30例。对照组给予西医常规治疗,治疗组在对照组基础上给予新加黄龙汤鼻饲,连续治疗3d,观察2组患者的一般情况(性别、年龄、中毒剂量、中毒程度、中毒后就诊时间等)、救治效果(炎症因子、肝功能、排便时间、并发症等)、住院时间及治愈率。结果:2组治疗后白介素-6(IL-6)、谷草转氨酶(AST)、胆碱酯酶(ChE)水平均下降,且明显低于各自治疗前的水平,治疗后治疗组的IL-6、AST、ChE水平也低于对照组,差异有统计学意义。治疗组在肠梗阻、应激性溃疡、中间综合征的发生率上<对照组,治愈率高于对照组,但无差异性;治疗组首次排便时间明显<对照组,治疗组每日排便次数多于对照组,差异有统计学意义;2组在住院时间上相当。结论:新加黄龙汤鼻饲配合西医常规疗法能够减轻急性有机磷农药中毒患者的炎症反应,改善患者转氨酶,提升ChE水平,缩短排便时间,增加排便次数,一定程度上减少并发症的发生,提升治愈成功率,值得在临床上推广应用。Objective:To observe the clinical efficacy of nasogastric administration of Xinjia Huanglong Decoction in the treatment of patients with acute organophosphorus pesticide poisoning(AOPP).Methods:A total of 60 patients with acute organophosphorus pesticide poisoning(AOPP)admitted to Bozhou Traditional Chinese Medicine Hospital from January 2022 to October 2023 were selected and randomly divided into 2 groups,30 cases in each group.The control group was given conventional Western medicine treatment,and the treatment group was given nasogastric adminis-tration of Xinjia Huanglong Decoction on the basis of the control group.The treatment lasted for 3 days.The general conditions(sex,age,poisoning dose,degree of poisoning,time of consultation after poisoning,etc.),treatment effects(inflammatory factors,liver function,defecation time,complications,etc.),hospitalization time and cure rate of the two groups were observed.Results:After treatment,the levels of IL-6,AST,and ChE in the two groups decreased,and were significantly lower than the levels before treatment.After treatment,the levels of IL-6,AST,and ChE in the treatment group were also lower than those in the control group,and the difference was statistically significant.The incidence of intestinal obstruction,stress ulcer and intermediate syndrome in the treatment group was lower than that in the control group,and the cure rate was higher than that in the control group,but there was no difference;the first defecation time in the treatment group was significantly shorter than that in the control group,and the number of daily defecation in the treatment group was more than that in the control group,and the difference was statistically significant;the two groups were equivalent in terms of hospital stay.Conclusion:Xinjia Huanglong Decoction nasogastric feeding combined with conventional Western medicine therapy can reduce the inflammatory response of patients with acute organophosphorus pesticide poisoning,improve patients’transaminase,increase cholinesterase(ChE)lev

关 键 词：新加黄龙汤 急性有机磷农药中毒 扶正通腑 临床疗效 

分 类 号：R278[医药卫生—中医学]