基于“阳化气,阴成形”理论探讨线粒体能量代谢障碍对心肌缺血损伤的影响  

Effects of mitochondrial energy metabolism disorders on myocardial ischemic injury based on the theory of"yang transforming into qi and yin constituting form"

作　　者：郭闫闫 袁茜茜 赵明芬 GUO Yanyan;YUAN Xixi;ZHAO Mingfen(The Fourth Clinical Medical College,Xinjiang Medical University,Urumqi,Xinjiang 830000,China;Cadre Office,Chinese Medicine Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830099,China)

机构地区：[1]新疆医科大学第四临床医学院,新疆乌鲁木齐830000 [2]新疆医科大学附属中医医院干部科,新疆乌鲁木齐830099

出　　处：《湖南中医药大学学报》2024年第8期1500-1504,共5页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(82160876);新疆特高发病中医诊治方案与特色中药创新开发研究(2022A03019-1)。

摘　　要：在心肌缺血损伤的病理过程中,线粒体能量代谢障碍是心肌细胞凋亡或坏死的关键因素。因此,靶向线粒体的干预策略对心肌缺血损伤的防治具有现实意义。“阳化气,阴成形”理论是阴阳含义的具体化,可以概括现代医学有关心肌缺血损伤的病理演变过程。线粒体功能障碍-阳化气不及-气化障碍是疾病病理过程的基础,阴成形太过-心肌能量代谢异常-有形实邪积聚是疾病病理过程的关键。谨遵病机特点,阐明扶阳补虚、抑阴祛邪的中医治疗原则对心肌缺血线粒体能量代谢机制的指导作用,以期为后续临床治疗和基础研究提供更多思路。During the pathological process of myocardial ischemic injury,and mitochondrial energy metabolism disorders are a key factor in myocardial cell apoptosis and necrosis.Therefore,the intervention strategy targeting mitochondria has practical significance for the prevention and treatment of myocardial ischemic injury.The theory of"yang transforming into qi and yin constituting form"is a concrete interpretation of the meaning of yin and yang,which can summarize the pathological evolution process of myocardial ischemia injury in modern medicine.Mitochondrial dysfunction-failure of yang transforming into qi-qi transformation disorder is the basis of the pathological process of diseases,while excessive form constitution of yin-abnormal myocardial energy metabolism-accumulation of tangible excess pathogens is the key to the pathological process of diseases.Adhering to the characteristics of the pathogenesis,this study elucidates the guiding role of the Chinese medicine treatment principles of tonifying yang and supplementing deficiency,submerging yin and eliminating pathogenic factors in the mitochondrial energy metabolism mechanism of myocardial ischemia,in order to provide more ideas for subsequent clinical treatment and basic research.

关 键 词：心肌缺血损伤 线粒体功能 心肌能量代谢 阳化气 阴成形 

分 类 号：R256.2[医药卫生—中医内科学]