叶天士通络法治疗痹症特色用药规律研究  

Research on the characteristic medication rules of Ye Tianshi Tongluo method for treating rheumatism

作　　者：潘赐明 王诗琪 张书涵 李佩佩[5] 吴元洁[5] 张思源 武玉珠 PAN Ciming;WANG Shiqi;ZHANG Shuhan(Yunnan University of Traditional Chinese Medicine School of Basic Medicine,Kunming Yunnan 650500,China;Key Laboratory of Sustainable Utilization of Yunnan Southern Medicine,Kunming Yunnan 650500,China;College of Life Sciences,Anhui Agricultural University,Hefei Anhui 230036,China;Anhui Medical University First Affiliated Hospital,Hefei Anhui 230022,China)

机构地区：[1]云南中医药大学基础医学院,云南昆明650500 [2]云南省南药可持续利用研究重点实验室,云南昆明650500 [3]安徽农业大学生命科学学院,安徽合肥230036 [4]安徽医科大学第一附属医院,安徽合肥230022 [5]安徽中医药大学,安徽合肥230038

出　　处：《四川中医》2024年第8期73-81,共9页Journal of Sichuan of Traditional Chinese Medicine

基　　金：新安医学教育部重点实验室开放项目(编号:2022XAYX11);云南省南药可持续利用研究重点实验室2021年开放课题云南省科技人才和平台计划项目(编号:202105AG070012XS2242);安徽中医药大学大学生创新创业省级项目(编号:S202310369148).

摘　　要：基于中医久病入络理论,通络法治疗痹症具有独特优势,故借助古今医案云平台、SPSS Modeler和中医药整合药理学研究平台v2.0对通络法治疗痹症的“病-证-症-方-药-靶”多维网络全方位进行深入研究。总结《临证指南医案》治疗痹症的“病-证-症-方-药”规律以及内在联系,梳理《临证指南医案》治疗痹症的常用通络法以及用药规律,解释不同通络法治疗痹症的物质基础和生物学机制,从病的层面为中医药治疗痹症处方选药提供临床依据,从证的层面为通络法治疗痹症的潜在药物发现及实验研究提供参考。In particular,Arthralgia syndrome has a long course of disease,based on the theory that chronic diseases enter the collateral,The Tongluo method has unique advantages in treating arthralgia.Therefore,with the help of the ancient and modern medical record cloud platform,SPSS Modeler,and the integrated pharmacology research platform v2.0of traditional Chinese medicine,a comprehensive study is conducted on the multi-dimensional network of“disease syndrome syndrome formula drug target”of Tongluo method in treating arthralgia,summarizing the“disease syndrome formula drug”laws and internal connections of the“Clinical Guidelines Medical Record”in treating arthralgia,Sort out the commonly used meridian unblocking methods and medication patterns in the“Clinical Guidelines Medical Record”for treating Bi syndrome,explain the material basis and biological mechanisms of different meridian unblocking methods for treating Bi syndrome,provide clinical basis for selecting traditional Chinese medicine prescriptions for treating Bi syndrome from the disease level,and provide reference for potential drug discovery and experimental research of meridian unblocking methods for treating Bi syndrome from the syndrome level.

关 键 词：叶天士 临证指南医案 痹症 病-证-症-方-药-靶 数据挖掘 中医药整合药理学 

分 类 号：R249[医药卫生—中医临床基础]