复律汤联合利伐沙班对房颤患者心功能及心电图参数的影响  

Influenceof Fulv decoction combined with rivaroxaban on cardiac function and electrocardiogram parameters in patients with atrial fibrillation

作　　者：李伟 黄晓平 朱鸣 周敏 LI Wei;HUANG Xiaoping;ZHU Ming(Department of Internal Medicine,Wusheng Hospital of Traditional Chinese Medicine,Wusheng Sichuan 638400,China;Department of Integrative Medicine,Zhongshan Hospital,Fudan University,Shanghai 200000,China)

机构地区：[1]武胜县中医医院内三科,四川武胜638400 [2]复旦大学附属中山医院中西医结合科,上海200000

出　　处：《四川中医》2024年第8期105-108,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(82204836)。

摘　　要：目的:探究复律汤联合利伐沙班对房颤患者心功能及心电图参数的影响。方法:选取我院2021年6月~2023年11月收治的118例房颤患者为研究对象。按照随机数字表法将其分为对照组与观察组,各59例,两组均予以常规治疗,对照组在常规治疗基础上予以利伐沙班治疗,观察组予以利伐沙班联合复律汤治疗。比较两组治疗前后中医证候积分、心功能[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)]、心电图参数[最大P波时限(Pmax)、P波离散度(Pdis)]、生化指标[N端B型利钠肽(NT-pro BNP)、转化生长因子(TGF)-β1]。结果:治疗后,两组各项证候积分、LVESD、LVEDD、Pmax、Pdis、血清NT-pro BNP与TGF-β1水平均降低,且观察组降幅高于对照组(P<0.05);两组LVEF均升高,且观察组升幅均高于对照组(P<0.05)。结论:复律汤联合利伐沙班应用于房颤患者,可有效改善其临床症状、心功能及心房电传导,其作用机制可能与抑制NT-pro BNP、TGF-β1水平相关。Objective:To explore the influence of Fulv decoction combined with rivaroxaban on cardiac function and electrocardiogram parameters in patients with atrial fibrillation(AF).Methods:118patients with AF in our hospital were selected from June 2021to November 2023as the research subjects.According to the random number table method,they were classified into control group(59cases)and observation group(59cases).Both groups were given routine treatment,and the control group was treated with rivaroxaban on the basis of routine treatment,while the observation group was given rivaroxaban combined with Fulv decoction.TCM syndromes scores,cardiac function[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],electrocardiogram parameters[maximum P wave duration(Pmax),P wave dispersion(Pdis)]and biochemical indicators[N-terminal pro-B-type natriuretic peptide(NT-pro BNP),Journal of Sichuan of Traditional Chinese Medicine transforming growth factor(TGF)-β1]were compared between groups before and after treatment.Results:After treatment,the various syndromes scores,LVESD,LVEDD,Pmax,Pdis,serum NT-pro BNP and TGF-β1levels in the two groups were decreased,and the decreases in observation group were higher compared to control group(P<0.05).The LVEF was increased in both groups,and the increase was higher in observation group than that in control group(P<0.05).Conclusion:Fulv decoction combined with rivaroxaban can effectively improve the clinical symptoms,cardiac function and atrial electrical conduction in patients with atrial fibrillation,and its role mechanism may be related to the inhibitions of NT-pro BNP and TGF-β1.

关 键 词：房颤 复律汤 利伐沙班 心功能 心电图 

分 类 号：R541.75[医药卫生—心血管疾病]