化瘀去疣汤内服外用治疗对扁平疣患者中医证候、血清免疫球蛋白及复发的影响  

Effects of of internal and external administration of Huayu Quyou Decoction on TCM syndromes,serum immunoglobulins and recurrence in patients with flat wart

作　　者：阳眉[1] 唐文龙 曲善忠[1] 程孝顶[1] 彭丽 陈明[1] YANG Mei;TANG Wenlong;QU Shanzhong(Dermatology Department,Chengdu Second People’s Hospital,Chengdu Sichuan 610017,China)

机构地区：[1]成都市第二人民医院皮肤科,四川成都610017

出　　处：《四川中医》2024年第8期176-180,共5页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨化瘀去疣汤内服外用治疗对扁平疣患者中医证候、血清免疫球蛋白及复发的影响。方法:选取2021年8月~2023年8月收治的132例扁平疣患者,按照随机数表法分为观察组和对照组各66例,对照组采用常规药物治疗,观察组在对照组的基础上采用化瘀去疣汤内服外用治疗,比较两组临床疗效、中医证候积分(皮疹颜色、瘙痒感、身热口干、便干尿黄)、血清免疫球蛋白[IgG、IgA、IgM]、免疫细胞因子[IL-2、IL-10、IFN-γ]及复发率。结果:观察组总有效率高于对照组(P<0.05);治疗后,观察组的中医症候积分(皮疹颜色、瘙痒感、身热口干、便干尿黄)低于对照组(t=6.114;t=5.552;t=6.705;t=5.435,P<0.05);治疗后,观察组血清IgG、IgA、IgM水平高于对照组(t=4.056;t=3.630;t=5.918,P<0.05);治疗后,观察组血清IFN-γ、IL-2高于对照组,IL-10低于对照组(t=9.462;t=5.429;t=8.314,P<0.05);随访6个月,观察组复发率低于对照组(4.55%vs 16.67%,χ2=5.114,P<0.05)。结论:化瘀去疣汤内服外用治疗扁平疣患者的效果显著,可有效提高免疫球蛋白水平,改善免疫细胞因子,降低复发率。Objective To explore the effects of internal and external administration of Huayu Quyou Decoction on TCM syndromes,serum immunoglobulins and recurrence in patients with flat wart.Methods A total of 132patients with flat wart were enrolled as the research objects between August 2021and August 2023.According to random number table method,they were divided into observation group and control group,66cases in each group.The control group was treated with routine drugs,while observation group was additionally treated with Huayu Quyou Decoction for internal and external administration.The clinical curative effect,scores of TCM syndromes(color of skin rash,itching,general fever and dry mouth,dry stool and yellow urine),serum immunoglobulins[immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM)],immune cytokines[interleukin-2(IL-2),interleukin10(IL-10),interferonγ(IFN-γ)]and recurrence rate were compared between the two groups.Results The total response rate of observation group was higher than that of control group(P<0.05).After treatment,scores of TCM syndromes(color of skin rash,itching,general fever and dry mouth,dry stool and yellow urine)in observation group were lower than those in control group(t=6.114;t=5.552;t=6.705;t=5.435,P<0.05),levels of serum IgG,IgA and IgM were higher than in control group(t=4.056;t=3.630;t=5.918,P<0.05),levels of IFN-γand IL-2were higher than those in control group,while IL-10level was lower than in control group(t=9.462;t=5.429;t=8.314,P<0.05).After 6months of follow-up,recurrence rate of observation group was lower than that of control group(4.55%vs 16.67%,χ2=5.114,P<0.05).Conclusion Curative effect of internal and external administration of Huayu Quyou Decoction is significant in patients with flat wart,which can effectively increase levels of immunoglobulins,improve immune cytokines and reduce recurrence rate.

关 键 词：扁平疣 化瘀去疣汤 中医证候 免疫球蛋白 复发 

分 类 号：R752.52[医药卫生—皮肤病学与性病学]