巨噬细胞在动脉粥样硬化中的作用与机制  

The role and mechanism of macrophages in atherosclerosis

作　　者：周宇恒 董新年 李玥潼 朱顶立 李立志 李仔豪 蒋植成 ZHOU Yuheng;DONG Xinnian;LI Yuetong;ZHU Dingli;LI Lizhi;LI Zihao;JIANG Zhicheng(Faculty of Medicine,Nantong University Xinglin College,Nantong 226236,Jiangsu Province,China;Department of Clinical Medicine,Kangda College of Nanjing Medical University,Lianyungang 222000,Jiangsu Province,China;Department of Rehabilitation Medicine,Suqian First Hospital Affiliated to Nanjing Medical University,Suqian 223800,Jiangsu Province,China;Medical School,Nantong University,Nantong 226001,Jiangsu Province,China)

机构地区：[1]南通大学杏林学院医学部,江苏南通226236 [2]南京医科大学康达学院临床医学部,江苏连云港222000 [3]南京医科大学附属宿迁第一人民医院康复医学科,江苏宿迁223800 [4]南通大学医学院,江苏南通226001

出　　处：《数理医药学杂志》2024年第8期575-583,共9页Journal of Mathematical Medicine

摘　　要：动脉粥样硬化(atherosclerosis,AS)是一种慢性炎症性疾病,是多种心脑血管病的主要病变基础,也是导致死亡的主要原因之一。巨噬细胞是AS斑块中主要的免疫细胞,且与疾病的进展密切相关,其生物学特性、表型比例和分泌的细胞因子决定了AS斑块的稳定性、大小和病变进展状况,因此,巨噬细胞被视为治疗AS强有力的靶点。本文从巨噬细胞极化特性、巨噬细胞调控AS的潜在分子机制,及靶向调控巨噬细胞极化对AS的影响等方面进行阐述,以期为更深入研究AS发病的分子机制和提高其治疗效果提供理论依据。Atherosclerosis(AS)is a chronic inflammatory disease,which is the main pathological basis of many cardiovascular and cerebrovascular diseases,and one of the main causes of death.Macrophages are the main immune cells in AS plaques and are closely related to the progression of the disease.Their biological characteristics,phenotype proportion,and secreted cytokines determine the stability,size,and lesion progression of AS plaques.Therefore,macrophages are considered a powerful target for treating AS.This article elaborates on the polarization characteristics of macrophages,the potential molecular mechanisms of macrophage regulation of AS,and the impact of targeted regulation of macrophage polarization on AS,in order to provide theoretical basis for further research on the molecular mechanisms of AS pathogenesis and improve its therapeutic effect.

关 键 词：动脉粥样硬化 巨噬细胞 炎症 极化 靶点 

分 类 号：R543.5[医药卫生—心血管疾病]