2013—2022年河南省开封市HIV/AIDS病例抗病毒治疗效果及影响因素  

Virological effects and influencing factors of antiviral treatment on HIV/AIDS cases in Kaifeng City,Henan Province,2013-2022

作　　者：贠赟[1] 杨爽 孙清洁 韩丹[1] 王亚辉 YUN Yun;YANG Shuang;SUN Qingjie;HAN Dan;WANG Yahui(Kaifeng Center for Disease Control and Prevention,Kaifeng,Henan 475000,China)

机构地区：[1]开封市疾病预防控制中心,河南开封475000

出　　处：《现代疾病预防控制》2024年第8期626-630,共5页MODERN DISEASE CONTROL AND PREVENTION

摘　　要：目的分析开封市艾滋病病毒感染者/艾滋病患者(HIV/AIDS)抗病毒治疗后病毒载量结果及其影响因素。方法采用回顾性研究方法,通过艾滋病防治基本信息系统收集2013年1月1日—2022年12月31日开封市15岁及以上HIV/AIDS病例相关信息,分析病毒载量结果及影响因素。结果在纳入分析的1264例病例中,经过抗病毒治疗,病毒载量<50拷贝/m L的占86.4%,50~1000拷贝/m L的占7.1%,≥1000拷贝/m L的占6.5%。病毒学治疗失败112例(8.9%),多因素logistic回归分析显示,年龄41~<66岁、≥66岁[以15~<41岁为参照,41~<66岁、≥66岁OR值(95%CI)分别为2.057(1.308~3.234)、3.206(1.499~6.859)],确证到开始治疗时间>12个月[以≤1个月为参照,>12个月的OR值(95%CI)为2.436(1.363~4.355)]发生病毒学治疗失败的风险更高;治疗时间1~<3年、3~<5年、>5年[以<1年为参照,1~<3年、3~<5年、>5年的OR值(95%CI)分别为0.196(0.111~0.346)、0.190(0.108~0.335)、0.127(0.072~0.222)]发生病毒学治疗失败的风险更低。结论开封市HIV/AIDS病例抗病毒治疗效果较好,应加大宣传,提高早期发现能力,关注40岁以上患者,定期随访检测,加强医患沟通,确保患者得到长期规范的治疗。Objective To analyze the results and influencing factors of viral load of HIV/AIDS cases in Kaifeng after antiviral treatment.Methods A retrospective study was conducted.Information related to HIV/AIDS cases over 15 years old in Kaifeng from January 1,2013 to December 31,2022 was collected through the Basic Information System for AIDS Prevention and Control.The results and influencing factors of viral load were analyzed.Results Of the 1264 HIV/AIDS cases included in the analysis,86.4%had viral load of less than 50 copies/m L,7.1%had viral load of 50-1000 copies/m L,and 6.5%had viral load of≥1000copies/mL after antiviral treatment.Virological treatment failure occurred in 112(8.9%)cases.Multivariate logistic regression analysis demonstrated that the OR(95%CI)were 2.057(1.308-3.234)and 3.206(1.499-6.859)for the groups of 41-<66 years old and≥66 years old(taking the group of 15-<41 years old as a reference),respectively,and 2.436(1.363-4.355)for the group with time intervals between HIV diagnosis and ART initiation>12 months(taking the group≤1 month as a reference),suggesting that the groups aged 41-<66 years old and≥66 years old aged,and the group with time intervals between HIV diagnosis and ART initiation>12 had a higher risk of virological treatment failure;taking the group with treatment<1 year as a reference,the OR(95%CI)for the groups with treatment between 1 to<3 years,3-<5 years,and>5 years were 0.196(0.111-0.346),0.190(0.108-0.335),and 0.127(0.072-0.222),respectively,suggesting that the groups with treatment intervals between 1-<3 years,3-<5 years,and more than 5years had a lower risk of virological treatment failure.Conclusions The antiviral treatment for HIV/AIDS cases in Kaifeng was effective.To ensure that patients get long-term standardized treatment,we should increase publicity,improve the ability of early detection,focus on patients over 40 years old,perform regular follow-up tests and strength communication of doctor-patient.

关 键 词：HIV/AIDS 抗病毒治疗 病毒载量 影响因素 

分 类 号：R512.91[医药卫生—内科学]