Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow  

作　　者：Hao Zhang Jie Feng Shiyu Zhang Wenjia Liu Lin Ma 

机构地区：[1]Chinese PLA Medical School,Beijing 100853,China [2]Department of Radiology,First Medical Center,Chinese PLA General Hospital,Beijing 100853,China [3]Department of Radiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China

出　　处：《Biomedical and Environmental Sciences》2024年第8期887-896,共10页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81741115);Military Creative Project(No.16CXZ014);Military Healthcare Project(No.16BJZ11)。

摘　　要：Objective To investigate the role of sea-level cerebral blood flow(CBF)in predicting acute mountain sickness(AMS)using three-dimensional pseudo-continuous arterial spin labeling(3D-pCASL).Methods Forty-eight healthy volunteers reached an altitude of 3,650 m by air after undergoing a head magnetic resonance imaging(MRI)including 3D-pCASL at sea level.The CBF values of the bilateral anterior cerebral artery(ACA),middle cerebral artery(MCA),posterior cerebral artery(PCA),and posterior inferior cerebellar artery(PICA)territories and the laterality index(LI)of CBF were compared between the AMS and non-AMS groups.Statistical analyses were performed to determine the relationship between CBF and AMS,and the predictive performance was assessed using receiver operating characteristic(ROC)curves.Results The mean cortical CBF in women(81.65±2.69 mL/100 g/min)was higher than that in men(74.35±2.12 mL/100 g/min)(P<0.05).In men,the cortical CBF values in the bilateral ACA,PCA,PICA,and right MCA were higher in patients with AMS than in those without.Cortical CBF in the right PCA best predicted AMS(AUC=0.818).In women,the LI of CBF in the ACA was different between the AMS and non-AMS groups and predicted AMS with an AUC of 0.753.Conclusion Although the mechanism and prediction of AMS are quite complicated,higher cortical CBF at sea level,especially the CBF of the posterior circulatory system,may be used for prediction in male volunteers using non-invasive 3D-pCASL.

关 键 词：Acute mountain sickness High-altitude headache Cerebral blood flow Arterial spin labeling Magnetic resonance imaging 

分 类 号：R594.3[医药卫生—内科学]