军事飞行员年度体检高尿酸血症调查分析  

Investigation and analysisof hyperuricemia in annual physical examination of military pilots

作　　者：宋媛媛 康阳 尹慧 祝玉慧 Song Yuanyuan;Kang Yang;Yin Hui;Zhu Yuhui(Department of Special Service,960th Hospital of PLA,Jinan 250000,China;271901 Force Health Company of PLA,Liaocheng 252000,China;Cadre Ward,960th Hospital of PLA,Jinan 250000,China)

机构地区：[1]解放军第九六〇医院特勤科,济南250000 [2]解放军71901部队卫生连,聊城252000 [3]解放军第九六〇医院干部病房,济南250000

出　　处：《航天医学与医学工程》2024年第4期241-244,共4页Space Medicine & Medical Engineering

摘　　要：目的探讨军事飞行员高尿酸血症的患病率及影响因素,为高尿酸血症的防治提供客观依据。方法以2020—2021年在我院例行年度体检的389名飞行员为研究对象,分析高尿酸血症的检出率,比较不同体重指数(BMI)、机种、飞行时间的飞行员尿酸(UA)值,并以UA为因变量,空腹血糖、收缩压、舒张压、BMI、血清肌酐、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯和葡萄糖指数(TyG指数)、半胱氨酸蛋白酶抑制剂C(Cys-C)等指标为自变量,进行多因素Logistic回归分析,明确UA值与这些指标的关系。结果在389名飞行员中,高尿酸血症46例,总检出率为11.83%;不同BMI组间的平均UA值差异有统计学意义(F=5.333,P=0.005),而各机种及飞行时间组间的平均UA值无统计学差异(F=1.502,P=0.224;F=0.375,P=0.866)。Logistic多因素回归分析显示,血清肌酐(OR=1.09,P<0.01)、TG(OR=5.10,P<0.01)、HDL-C(OR=0.14,P<0.01)、LDL-C(OR=1.99,P<0.05)、TyG指数(OR=2.15,P<0.05)是高尿酸血症的独立危险因素。结论血清肌酐、血脂水平、TyG指数与高尿酸血症密切相关。Objective To investigate the prevalence and related factors of hyperuricemia in military pilots,and to provide an objective basis for the prevention and treatment of hyperuricemia.Methods A total of 389 pilots who underwent annual physical examination in our department from 2020 to 2021 were selected as the research objects.The detection of hyperuricemia was analyzed,and the serum uric acid values of pilots with different body mass index,type of aircraft and flight time were compared.Logistic multiple regression analysis was performed with serum uric acid(UA)as the dependent variable,fasting blood glucose systolic blood pressure,diastolic blood pressure,body mass index(BMI),serum creatinine,total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),triglyceride and glucose index(TyG index),cystine protease inhibitor C(Cys-C)and other indicators as independent variables to clarify the relationship between UA value and these indicators.Results Among the 389 pilots,there were 46 cases of hyperuricemia,and the total detection rate was 11.83%.According to the occupational related factors BMI,aircraft type and flight time,the average UA values of pilots with different BMI groups were statistically significant(F=5.333,P=0.005),while the average UA values of pilots with different aircraft types and flight time groups were not statistically significant(F=1.502,P=0.224;F=0.375,P=0.866).Logistic multiple regression analysis showed that creatinine(OR=1.09,P<0.01),triglyceride(OR=5.10,P<0.01),high density lipoprotein(OR=0.14,P<0.01),low density lipoprotein(OR=1.99,P<0.05)and TyG index(OR=2.15,P<0.05)were independent risk factors for hyperuricemia.Conclusion Creatinine,blood lipid level and TyG index are closely related to hyperuricemia.

关 键 词：飞行员 血脂 TyG指数 高尿酸血症 相关因素 

分 类 号：R851.3[医药卫生—航空、航天与航海医学]