身体成分与儿童血压关系的系统评价/Meta分析  

Association between body composition and blood pressure in children:A systematic review and meta-analysis

作　　者：张杰[1] 肖雨晴 吴梦 刘琴[1] ZHANG Jie;XIAO Yuqing;WU Meng;LIU Qin(Research Center for Medicine and Social Development,School of Public Health,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学公共卫生学院,医学与社会发展研究中心,重庆400016

出　　处：《中国循证儿科杂志》2024年第3期183-189,共7页Chinese Journal of Evidence Based Pediatrics

摘　　要：背景身体成分是体内各种成分的含量,其与儿童血压的关联存在争议。目的探讨身体成分与儿童血压的关联性。设计系统综述/Meta分析。方法计算机检索中国生物医学数据库、维普中文科技期刊数据库、中国知网期刊数据库、万方数据在线知识服务平台4个中文数据库和PubMed、Web of Science和EBSCO 4个外文数据库,检索起止时间均为各数据库建库至2023年8月8日。纳入身体成分与儿童血压关系的队列研究。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,对结果进行定量和定性归纳总结。主要结局指标身体成分与儿童高血压的相关性。结果共纳入9项身体成分与儿童舒张压和收缩压的纵向队列研究,其中7个队列报告了脂肪质量相关指标与儿童舒张压和收缩压的相关性,儿童期脂肪质量百分比与儿童舒张压和收缩压呈正相关,其他脂肪质量指标研究结论仍不一致。2个队列报告了非脂肪质量指标与儿童血压的相关性,研究结论不统一。3个队列报告了脂肪质量与儿童期血压偏高和高血压的发生呈正相关,但新生儿脂肪质量与6岁时高血压的风险可能为负相关。结论儿童期脂肪质量百分比与儿童舒张压和收缩压呈正相关,身体成分对儿童血压有一定影响。Background Body composition is the content of various components in the body and its association with childhood blood pressure remains controversial.Objective To investigate the association between body composition and blood pressure in children.Design Systematic review/Meta-analysis.Methods We conducted computer searches in four Chinese databases(CNKI,Wanfang Data,VIP and CBM),as well as four international databases(PubMed,Web of Science,and EBSCO)from inception to August 8,2023.We included longitudinal cohort studies examining the relationship between body composition and childhood blood pressure.Two reviewers independently screened the literature,extracted data,and assessed the risk of bias in the included studies.We summarized the results quantitatively and qualitatively.Main outcome measures Association between body composition and childhood hypertension.Results A total of 9 longitudinal cohort studies were included,investigating the longitudinal relationship between body composition and systolic and diastolic blood pressure in children.Seven of these studies reported the association of fat mass-related indicators with blood pressure in children,showing a positive correlation between childhood fat mass percentage and blood pressure.However,conclusions regarding other fat mass indicators were inconsistent.Two studies reported on the relationship between non-fat mass and childhood blood pressure with inconsistent findings.Three studies reported a positive correlation between fat mass and the occurrence of high systolic and diastolic blood pressure in childhood,although the risk of hypertension may be negatively correlated with neonatal fat mass.Conclusion The percentage of body fat in children is positively correlated with both diastolic and systolic blood pressure.Body composition has a significant impact on blood pressure in children.

关 键 词：儿童 身体成分 脂肪含量 骨骼肌质量 血压 系统评价 

分 类 号：R725.4[医药卫生—儿科]