电离辐射对人脑影响的脑电信号分析  

Effects of radiation on brain based on EEG signal

作　　者：何承宇 丰俊东[1] 孙向东 田刘欣 薄宏宇 孙思敏 付豪 李骞 He Chengyu;Feng Jundong;Sun Xiangdong;Tian Liuxin;Bo Hongyu;Sun Simin;Fu Hao;Li Qian(Nanjing University of Aeronautics and Astronautics,College of Materials Science and Technology,Nanjing 211106,China;Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210016,China;COMAC Shanghai Aircraft Design&Research Institute,Shanghai 200120,China)

机构地区：[1]南京航空航天大学核科学与技术系,南京211106 [2]南京大学医学院附属金陵医院,南京210016 [3]中国商飞上海飞机设计研究院,上海200120

出　　处：《航天医学与医学工程》2024年第3期149-155,共7页Space Medicine & Medical Engineering

基　　金：载人航天基金项目(No.HYZHXM02004)。

摘　　要：目的空间辐射是影响航天员健康、工效的重要环境要素。本研究探索辐射对脑电信号的影响规律,以期为深入研究辐射对中枢神经系统(脑)损伤作用提供参考。方法采集放疗志愿者接受射线辐射前后的静息态脑电信号(EEG),通过频谱分析、非线性动力学特征分析、相关系数和微状态分析等方法,研究辐射对EEG的影响规律。结果辐射诱导EEG频谱出现“慢波化”现象,重心频率、样本熵和复杂度下降,疲劳指标上升。EEG微状态C的平均持续时间和频率下降,微状态A与微状态C的平均相关系数上升,微状态D的平均持续时间下降。结论辐射导致神经元兴奋性下降,可能影响认知脑网络和大脑注意力。本研究可为辐射对中枢神经系统(脑)损伤研究提供依据。Objective Space radiation is an important environmental factor affecting the health and efficiency of astronauts.To explore the effects of radiation on electroencephalogram(EEG)signal,and to provide references for further study of the effects of radiation on Central Nervous System(brain)injury.Methods The resting state EEG of radiotherapy volunteers were collected before and after X-ray exposure.The effects of radiation on EEG was studied by means of spectral analysis,nonlinear dynamic characteristic analysis,correlation coefficient analysis and microstate analysis.Results The results show that radiation induced a“slow wave”phenomenon in the EEG spectrum,with a decrease in Gravity Frequency,Sample Entropy,and Lempel-Ziv Complexity,and an increase in Fatigue Index.The average duration and frequency of EEG microstate C both significantly decreased,and the proportion of time for microstate D decreased,while the average correlation coefficient between microstates A and C increased.Conclusion A decrease was induced by radiation in neuronal excitability,which may affect cognitive brain networks and brain attention.This study can provide reference for the study of radiation damage to the Central Nervous System(brain).

关 键 词：脑电图信号 辐射 大脑 慢波化 微状态 

分 类 号：R85[医药卫生—航空、航天与航海医学]