估计脉搏波速度与中国中老年人心脑血管疾病的关系  

Estimating the Relationship between Pulse wave Velocity and Cardiovascular Diseases in Chinese Middle-aged and Elderly People

作　　者：潘锦滨 张土明 陈建英 张兴斌 吴柱国 PAN Jin-bin;ZHANG Tu-ming;CHEN Jian-ying;ZHANG Xing-bin;WU Zhu-guo(The First Clinical School of Medicine,Guangdong Medical University,Zhanjiang,Guangdong,524000,China;Department of Cardiovascular Medicine,Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong,524000,China;Department of Cardiovascular Medicine,The First Dongguan Affiliated Hospital of Guangdong Medical University,Dongguan,Guangdong,320560,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524000 [2]广东医科大学附属医院心血管内科,广东湛江524000 [3]广东医科大学附属东莞第一医院心血管内科,广东东莞320560

出　　处：《现代生物医学进展》2024年第16期3087-3092,共6页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81370242);广东医科大学学科建设项目(4SG23012G)。

摘　　要：目的:探究估计脉搏波速度(ePWV)与我国社区中老年人心脑血管疾病的关系。方法:选取2011年-2012年第一波中国健康与养老追踪调查(CHARLS)的中老年人纳入本研究。收集人群一般资料及实验室指标,比较各组临床资料的差异。采用logistic回归分析探究ePWV对心脑血管疾病患病风险的影响。结果:共9542例研究对象纳入本研究,其中共1348例患者患有心脑血管疾病,在调整多变量的logistic回归分析模型中,无论作为连续变量还是分类变量,ePWV都与心脑血管疾病患病率显著相关。作为连续变量时,ePWV每增加1个单位,心脑血管疾病患病率增加8%(OR=1.08,95%CI:1.02-1.14,P=0.008)。亚组分析显示,在年龄<60岁、高中以下学历、已婚的亚组中,ePWV与心脑血管疾病关系显著,在年龄>60岁、女性、吸烟、饮酒(从不饮酒vs每月1次vs每月<1次)、BMI(<25vs≥25),ePWV与心脑血管疾病关系不显著。结论:ePWV是中国中老年人群心脑血管疾病的独立危险因素,可作为未来心脑血管疾病一级预防和监测的指标,但仍需更多的研究证实。Objective:To investigate the relationship between estimated pulse wave velocity(ePWV)and cardiovascular and cerebrovascular diseases in middle-aged and elderly people in China's community.Methods:Middle-aged and elderly people from the first wave of China Health and Retirement Longitudinal Study(CHARLS)in 2011-2012 were selected for this study.General information and laboratory indicators of the population were collected,and the differences in clinical information between the groups were compared.Logistic regression analysis was used to investigate the effect of ePWV on the risk of cardiovascular disease.Results:A total of 9,542 study subjects were included in this study,of which a total of 1,348 patients suffered from cardiovascular and cerebrovascular diseases.ePWV was significantly associated with the prevalence of cardiovascular and cerebrovascular diseases,both as a continuous and categorical variable,in the adjusted multivariate logistic regression analysis model.When used as a continuous variable,each 1 unit increase in ePWV was associated with an 8% increase in the prevalence of cardiovascular and cerebrovascular disease(OR=1.08,95%CI:1.02-1.14,P=0.008).Subgroup analysis showed that ePWV was significantly associated with cardiovascular and cerebrovascular diseases in the subgroups of age<60 years,less than high school education,and married.ePWV was not significantly associated with cardiovascular and cerebrovascular diseases in the subgroups of age>60 years,females,smokers,alcohol consumption(never vs.1 time per month vs.<1time per month),and BMI(<25 vs.≥25).Conclusion:ePWV is an independent risk factor for cardiovascular and cerebrovascular diseases in the middle-aged and elderly population in China,and can be used as an indicator for primary prevention and monitoring of cardiovascular and cerebrovascular diseases in the future,but more studies are still needed to confirm this.

关 键 词：心脑血管疾病 估计脉搏波速度 动脉硬化 中老年人 

分 类 号：R541[医药卫生—心血管疾病] R743[医药卫生—内科学]