可充电动物遥测系统在自然状态小鼠心电监测中的应用  

Application of a rechargeable animal telemetry system for ECG monitoring in natural state mice

作　　者：王晓燕 邵诗捷[1,2] 曹佳如 马嵋 张玲[1,2] WANG Xiaoyan;SHAO Shijie;CAO Jiaru;MA Mei;ZHANG Ling(Research Base Department of Clinical Medical Research Institute;State Key of High Incidence Diseases in Central Asia,Key Laboratory of Cardiac Electrophysiology and Cardiac Remodeling,the First Affiliated Hospital of Xinjiang Medical University;Department of Teaching Management,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院临床医学研究院科研基地科 [2]新疆医科大学第一附属医院省部共建中亚高发病成因与防治国家重点实验室,心电生理与心脏重塑重点实验室 [3]新疆医科大学第一附属医院教学管理科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2024年第8期1053-1060,共8页Journal of Xinjiang Medical University

基　　金：省部共建中亚高发病成因与防治国家重点实验室开放课题资助项目(SKL-HIDCA-2021-XXG5);新疆维吾尔自治区科技厅青年科技拔尖人才-青年科技创新人才项目(Q022TSYCCX0098)。

摘　　要：目的探讨可充电动物遥测系统在自然状态小鼠心电监测中的应用,并提供自然清醒状态小鼠的心电参数。方法20只C57小鼠(雌雄各半)安装植入式电极,连续记录小鼠全天24 h心电活动并分析其心电参数。结果20只C57小鼠均完成24 h监测。C57小鼠全天平均心率为(493.55±73.29)次/分。雌鼠全天平均心率为(522.83±63.70)次/分,最大心率673.60次/分,最小心率385.90次/分。雄鼠全天平均心率为(464.27±70.55)次/分,最大心率641.60次/分,最小心率321.50次/分。雌性小鼠的全天平均心率快于雄性小鼠,差异有统计学意义(P<0.05);雄性小鼠夜间平均心率较白天平均心率增快,差异有统计学意义(P<0.05)。白天07∶00-19∶00,夜间19∶00-次日07∶00小鼠相关心率变化指标结果显示,雌性小鼠白天平均心率较夜间平均心率增快,雄性小鼠白天平均心率较夜间平均心率减慢,差异有统计学意义(P<0.05)。麻醉状态下小鼠的心电指标结果显示,雌、雄小鼠P波振幅、P波时限以及RR间期差异具有统计学意义(P<0.05);雄性小鼠的QRS时限较雌性小鼠延长,差异有统计学意义(P<0.05);雌、雄小鼠QRS振幅以及QT间期差异无统计学意义(P>0.05)。结论可充电动物遥测系统可安全、微损伤地对自由活动状态的小鼠进行24小时心电参数记录,其记录的信号清晰、稳定,可用于正常及急慢性模型小鼠自然状态下心率及心律的监测。Objective:To explore the application of a rechargeable animal telemetry system for ECG monitoring in naturally awake mice and to provide ECG parameters in naturally awake mice.Methods:20 C57 mice(half male and half female)were fitted with implantable electrodes,and cardiac activity was continuously recorded and analyzed for cardiac parameters throughout the day for 24 hours.Results:20 C57 mice were monitored for 24 hours.The average heart rate of C57 mice was(493.55±73.29)beats per minute throughout the day.The average heart rate of female mice was(522.83±63.70)beats per minute throughout the day,with a maximum heart rate of 673.60 beats per minute and a minimum heart rate of 385.90 beats per minute.The average heart rate of male mice was(464.27±70.55)beats per minute throughout the day,with a maximum heart rate of 641.60 beats per minute and a minimum heart rate of 321.50 beats per minute.The average heart rate of female mice was faster than that of male mice,and the difference was statistically significant(P<0.05).The average heart rate of male mice was faster at night than during the day(P<0.05).The heart rate change indicators in the daytime(07∶00-19∶00)and nighttime(19∶00-the next day 07∶00)of male and female mice showed that the average heart rate of female mice increased faster during the day than at night.The average heart rate of male mice during the day was slower than that at night,and the difference was statistically significant(all P<0.05).The electrocardiographic indicators in anesthetized mice showed that there were statistically significant differences in P wave amplitude,P wave duration,and RR interval between male and female mice(P<0.05);the QRS duration of male mice was longer than that of female mice,and the difference was statistically significant(P<0.05);there were no statistically significant differences in QRS amplitude and QT interval between male and female mice(P>0.05).Conclusion:The rechargeable animal telemetry system can safely and minimally impair 24-hour ECG parameter re

关 键 词：可充电动物遥测系统 小鼠 自然状态 心电图 

分 类 号：R541.7[医药卫生—心血管疾病]