基于数据挖掘探究清代古籍关于乳中结核的外治方法与用药规律  

Based on data mining to explore the therapeutic methods and medication patterns of external treatment of tuberculosis of breast in ancient books of Qing Dynasty

作　　者：易嘉敏 陈思羽 谢丹[3] 李军[3] YI Jiamin;CHEN Siyu;XIE Dan;LI Jun(First school of Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou 51000,China;Second school of Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou 51000,China;First Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一临床医学院,广州510000 [2]广州中医药大学第二临床医学院,广州510000 [3]广州中医药大学第一附属医院乳腺外科,广州510405

出　　处：《新疆医科大学学报》2024年第8期1161-1165,1173,共6页Journal of Xinjiang Medical University

基　　金：广东省中医药科研项目(20231123)。

摘　　要：目的通过数据挖掘技术探究中国清代古籍中关于乳中结核的外治方法与用药规律。方法对《中国国家图书馆》(V6.16版)收录的清代古籍中出现的关于乳中结核的外治方法进行归类总结,并采用古今医案云平台软件(V2.3.5)统计频次前30味中药的归经、性味和功效,及对其进行聚类分析、关联规则分析以及社团分析。结果最终检索到关于乳中结核的清代古籍10本,记载的乳中结核的外治方法有外敷、艾灸、热疗、针刺4种。其中外用方共13首,中药53味,总频次为104次,频次≥3次者共10味,前三位分别是铅丹、麝香、麻油;药物功效以清热解毒、清热凉血、解毒散结为主;归经多为脾、肝、心,五味以辛、苦、甘为主,四气以温、寒、平为主;社团分析显示外用药物治法分为4类,分别是清热燥湿泻火、活血通络化痰、消肿敛疮生肌、行气活血散结;关联分析显示外用药方核心处方为琥珀膏;外用药中麻油和动物药2种特殊类型的药材出现频率较高。结论清代古籍中关于乳中结核有4种不同治疗方法,外用药物以寒温并用、标本兼顾、活血清散为主,并常用芳香类溶剂和血肉有情之品。Objective:Based on data mining technology,to explore the external treatments for lump in breast and the medication rule in ancient Chinese books of Qing Dynasty.Methods:All the external treatments appearing in the surgical monographs of Qing Dynasty included in National Library of China(Version V6.16)were classified and summarized,and the meridian distribution,the property and flavor and the efficacy of the top 30 Traditional Chinese medicines(TCM)in terms of frequency were counted by using the software of the Cloud Platform of Ancient and Modern Medical Cases(V2.3.5),and the software carried out the cluster analysis,the association rule analysis as well as the association analysis on the high TCM.Results:Eventually,a total of 10 Qing Dynasty surgical monographs were collected and examined,and 4 types of external treatments were recorded,namely:external application,moxibustion,thermotherapy and acupuncture.Among them,there were 13 relevant external prescriptions,53 major TCM,with a total frequency of 104 times,and 10 TCM with a frequency of more than 3 times.The top 3 were red lead,moschus and sesame oil.The efficacy of the drug was based on heat-clearing and detoxicating and removing heat to cool blood,diminishing stagnation by detoxification.The meridian distribution was mostly in the spleen,liver and heart.The 5 scents were predominantly pungent,bitter and sweet.The 4 natures of drugs were mainly warm,cold and calm.Analysis of the association showed that external drug treatments were divided into 4 categories,namely,clearing heat,drying dampness and purging fire,promoting blood circulation and resolving phlegm,eliminating swellings and astringent sores and regenerating muscles,promoting QI and activating blood circulation and dispersing knots.Correlation analyses revealed that the core prescription of the topical remedy was amber ointment.In addition,2 special types of herbs,sesame oil and animal drug,occurred more frequently in their topicals.Conclusion:There are 4 different treatment methods for tuberculosis

关 键 词：乳中结核 中医外治法 外科古籍 清代 

分 类 号：R289[医药卫生—方剂学]