炎症四项对溃疡性结肠炎严重程度的预测价值  

Predictive value of four items of inflammation for the severity of ulcerative colitis

作　　者：李媛 卢灿省[2] 鲍炳州 LI Yuan;LU Cancing;BAO Bingzhou(The First Clinical Medical College of Anhui University of Traditional Chinese Medicine,Hefei,230031,China;Department of Proctology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine)

机构地区：[1]安徽中医药大学第一临床医学院,合肥230031 [2]安徽中医药大学第一附属医院肛肠科

出　　处：《中国中西医结合消化杂志》2024年第8期707-710,715,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：目的:探讨炎症四项[C反应蛋白(C-reaction protein,CRP)、IL-6、血清淀粉样蛋白A(serum amyloid A,SAA)、降钙素原(procalcitonin,PCT)]在预测溃疡性结肠炎(ulcerative colitis,UC)严重程度方面的应用价值。方法:选取2020年12月—2023年12月在安徽中医药大学第一附属医院肛肠科住院治疗的UC患者为研究对象,将80例轻度患者设为对照组,155例中重度患者设为观察组。收集患者的临床资料及炎症四项数据。采用多因素logistic回归分析研究UC严重程度的影响因素,采用ROC曲线分析炎症四项对UC严重程度的预测效果。结果:观察组WBC、RBC、纤维蛋白原、CRP、IL-6、PCT、SAA均高于对照组(均P<0.001),血清白蛋白低于对照组(P<0.001)。多因素logistic回归分析结果显示,CRP、IL-6、PCT、SAA是UC严重程度的独立影响因素(P<0.001)。ROC曲线分析结果显示,CRP、IL-6、PCT、SAA及四者联合预测中重度UC的AUC分别为0.791、0.728、0.781、0.751、0.895;四者联合预测中重度UC的AUC均大于CRP、IL-6、PCT、SAA单独预测的AUC(均P<0.001)。结论:CRP、IL-6、PCT、SAA是UC严重程度的独立影响因素,且四者联合预测UC严重程度具备较高临床价值。Objective:This study will definitively determine the predictive value of inflammatory components,including C-reaction protein(CRP),procalcitonin(PCT),serum amyloid A(SAA),and IL-6,in identifying the severity of ulcerative colitis(UC).Methods:This research recruited UC patients who were hospitalized in the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from December 2020 to December 2023 of these,155 patients with moderate severity were placed in the observation group and 80 patients with mild severity were placed in the control group.Four data sets on inflammation and general patient information were gathered.ROC curves were utilized to analyze the prediction power of the four inflammatory indicators on the severity of UC,and multifactorial logistic regression analysis was employed to investigate the factors influencing UC severity.Results:Leukocyte count,erythrocyte count,fibrinogen(Fib),CRP,IL-6,PCT,and SAA were higher in the observation group than in the control group(P<0.001),albumin(ALB)was lower in the control group(P<0.001).The four predictor values for moderate to severe UC were 0.791,0.728,0.781,0.751,and 0.895,respectively,according to ROC curve analysis,which also revealed the values for CRP,IL-6,PCT,and SAA.The AUCs of the four combined predictors of moderate to severe UC were higher than those predicted by CRP,IL-6,PCT,and SAA alone,respectively(P<0.001).Conclusion:CRP,IL-6,PCT,and SAA are the independent factors affecting the severity of UC,and the combination of the four factors has a high value in predicting the severity of UC.

关 键 词：溃疡性结肠炎 C反应蛋白 IL-6 血清淀粉样蛋白A 降钙素原 预测价值 

分 类 号：R256.3[医药卫生—中医内科学]