尿液细胞外囊泡生物标志物研究新进展与挑战  

Progress and challenges in the research of urinary extracellular vesicles as disease biomarkers

作　　者：李柠 朱婷婷 吕林莉[1] Li Ning;Zhu Tingting;Lyu Linli(Department of Nephrology,Zhongda Hospital,Southeast University,Institute of Nephrology,Southeast University,Nanjing210009,China)

机构地区：[1]东南大学附属中大医院肾科、东南大学肾脏病研究所,南京210009

出　　处：《中华检验医学杂志》2024年第8期969-974,共6页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(82241045,82122011);国家重点研发计划(2022YFC2502503)。

摘　　要：尿液细胞外囊泡(uEV)是近年来备受关注的尿液中的重要组成成分。随着高通量组学及单个EV研究技术的进步, 人们对uEV的来源及其内容物有了更深入的认识。uEV内容物包括蛋白质、脂质、RNA和DNA等, 能够直接反映其来源器官的病理生理状态。uEV兼具高稳定性、可溯源性及内容物可富集性等特点, 在多系统疾病, 尤其是泌尿生殖系统疾病中显示出了独特的作为生物标志物的应用前景。Urinary extracellular vesicles(uEV)have recently garnered significant attention as crucial components in urine.Advances in high-throughput omics and single-vesicle technologies have deepened our understanding of the origins and contents of uEV,which include proteins,lipids,RNA,and DNA.These vesicles reflect the pathophysiological status of their source organs.uEV are highly stable,traceable,and can be enriched with various contents,making them promising biomarkers,particularly for urogenital diseases.

关 键 词：细胞外囊泡 外泌体 生物标志物 尿液 

分 类 号：R446.12[医药卫生—诊断学]