近红外荧光-光热纳米粒子在宫颈癌光热治疗中的应用研究  

Application of Near-Infrared Fluorescence Photothermal Nanoparticles in Photothermal Therapy of Cervical Cancer

作　　者：朱丽君 熊加宝 杜仲 马蓉[3] 张学良[2] 努尔尼沙·阿力甫 Zhu Lijun;Xiong Jiabao;Du Zhong;Ma Rong;Zhang Xueliang;Nuernisha Alifu(The Second Affiliated Hospital of Xinjiang Medical University,The Second School of Clinical Medicine,Xinjiang Medical University,Urumqi 830054,China;School of Medical Engineering and Technology,Xinjiang Medical University,Urumqi 830054,China;Department of Gynecology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第二附属医院第二临床医学院,乌鲁木齐830054 [2]新疆医科大学医学工程技术学院,乌鲁木齐830054 [3]新疆医科大学第一附属医院妇科,乌鲁木齐830054

出　　处：《中国生物医学工程学报》2024年第4期499-507,共9页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(62035011);省部共建中亚高发病成因与防治国家重点实验室开放课题重点项目(SKL-HIDCA-2022-3);新疆高发病防诊治关键技术研发与平台建立(ZYYD2022B06)。

摘　　要：宫颈癌的诊断和治疗技术的创新对提高患者生存率及预后具有重要意义。随着纳米医学在临床应用中的快速发展,基于荧光纳米材料的近红外荧光成像和光热疗法为宫颈癌诊疗带来新的突破以及提供新的思路,改善和解决了传统诊疗所面临的敏感性差、副作用大和术后转移发生率高等问题。以近红外荧光成像-光热疗法为出发点,综述了生物修饰纳米粒子的特性;以无创快速、精准诊疗和低毒副作用为特点,阐述了生物修饰光热纳米材料在光热治疗宫颈癌中的应用;以近红外荧光成像技术辅助光热疗法的研发为目标,聚焦于在临床前基础研究和临床中应用转化方面的发展潜力;介绍了新出现的近红外荧光-光热纳米粒子在宫颈癌临床诊疗一体化的临床前基础研究。Diagnosis and treatment of cervical cancer are of great significance to improve the survival rate and prognosis of patients.With the rapid development of nanomedicine in disease theranostics systems,near-infrared(NIR)fluorescence and photothermal therapy(PTT)based on fluorescent nanomaterials have provided promising solutions to improve the poor sensitivity,significant side effects and high incidence of postoperative metastasis in the diagnosis and treatment of cervical cancer.In this article,we reviewed the characteristics of bio-modified nanoparticles from NIR imaging and PTT,elaborated on the application of biologically modification new photothermal nanomaterials in the PTT of cervical cancer with the non-invasive,rapid,precise diagnosis and treatment,and low toxic side effects as the characteristic.Potentials of NIR imaging assisted PTT in preclinical research and clinical translation were discussed as well.Meanwhile,new NIR-photothermal nanoparticles and their preclinical experimental basis for translation to clinical treatment of cervical cancer were briefly introduced.

关 键 词：近红外荧光 光热治疗 无机光热剂 有机光热剂 宫颈癌 

分 类 号：R318[医药卫生—生物医学工程]