聚乙二醇干扰素α联合水飞蓟宾胶囊治疗对慢性乙型肝炎患者肝功能的影响  

Effect of pegylated interferonαcombined with silybin capsule on liver function in patients with chronic hepatitis B

作　　者：白兴刚 白满灵 陈斌 BAI Xing-gang;BAI Man-ling;CHEN Bin(Department of Liver Disease Infection,Wuwei People's Hospital,Wuwei 733000,China.)

机构地区：[1]武威市人民医院肝病感染科,甘肃武威733000

出　　处：《医师在线》2024年第8期48-51,共4页Journal of Doctors Online

摘　　要：目的分析聚乙二醇干扰素α联合水飞蓟宾胶囊对慢性乙型肝炎患者肝功能的影响。方法选取我院2021年3月~2024年1月收治的84例慢性乙型肝炎患者,随机分为对照组和研究组,各42例。对照组采用聚乙二醇干扰素α治疗,研究组采用聚乙二醇干扰素α联合水飞蓟宾胶囊治疗。比较两组患者的临床疗效、炎症因子水平、肝功能、肝纤维化情况及不良反应发生情况。结果治疗前,两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血清干扰素-γ(INF-γ)、转化生长因子-β(TGF-β)水平比较,差异无统计学意义(P>0.05);治疗后,研究组IL-6、TNF-α、TGF-β水平低于对照组,INF-γ水平高于对照组(P<0.05)。治疗前,两组血清总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(ALB)水平比较,差异无统计学意义(P>0.05);治疗后,研究组TBIL、ALT、AST水平低于对照组,ALB水平高于对照组(P<0.05)。治疗前,两组血清透明质酸(HA)、层黏连蛋白(LN)、Ⅳ型胶原(ⅣC)比较,差异无统计学意义(P>0.05);治疗后,研究组HA、LN、ⅣC水平低于对照组(P<0.05)。研究组治疗总有效率高于对照组(P<0.05),两组均未发生明显不良反应。结论聚乙二醇干扰素α联合水飞蓟宾胶囊治疗慢性乙型肝炎患者效果较好,且具有较高的安全性。Objective To analyze the effects of pegylated interferonαcombined with silybin capsule on liver function in patients with chronic hepatitis B.Methods A total of 84 patients with chronic hepatitis B in our hospital from March 2021 to January 2024 were randomly divided into control group and study group with 42 cases in each group.The control group was treated with pegylated interferonα.The study group was treated with pegylated interferonαcombined with silybin capsule.The clinical efficacy,levels of inflammatory factors,liver function,liver fibrosis and adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),serum interferon-γ(INF-γ)and transforming growth factor-β(TGF-β)between the two groups(P>0.05).After treatment,the levels of IL-6,TNF-αand TGF-βin the study group were lower than those in the control group,and the level of INF-γwas higher than that in the control group(P<0.05).Before treatment,there was no significant difference in serum total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and albumin(ALB)between the two groups(P>0.05).After treatment,the levels of TBIL,ALT and AST in the study group were lower than those in the control group,and the level of ALB was higher than that in the control group(P<0.05).Before treatment,there was no significant difference in serum hyaluronic acid(HA),laminin(LN)and typeⅣcollagen(ⅣC)between the two groups(P>0.05).After treatment,the levels of HA,LN andⅣC in the study group were lower than those in the control group(P<0.05).The total effective rate of the study group was higher than that of the control group(P<0.05),and no obvious adverse reactions occurred in both groups.Conclusion Pegylated interferonαcombined with silybin capsule is effective and safe in the treatment of chronic hepatitis B patients.

关 键 词：聚乙二醇干扰素Α 水飞蓟宾胶囊 慢性乙型肝炎 肝功能 

分 类 号：R512.62[医药卫生—内科学]