苦味受体调控巨噬细胞功能及其作用机制的研究进展  

Progress in regulation of macrophage function by bitter taste receptors and its mechanism

作　　者：王乐乐 方玉珍 马雨晴 赵子熙 马若男 王星[2] 张宇昕 WANG Lele;FANG Yuzhen;MA Yuqing;ZHAO Zixi;MA Ruonan;WANG Xing;ZHANG Yuxin(Key Laboratory of Ethnomedicine in Ministry of Education,School of Pharmacy,Minzu University of China,Beijing 100081,China;Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research,School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China)

机构地区：[1]中央民族大学药学院,民族医药教育部重点实验室,北京100081 [2]首都医科大学中医药学院,北京市络病重点实验室,北京100069

出　　处：《中国病理生理杂志》2024年第8期1520-1528,共9页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金青年项目(No.82204644);国家自然科学基金面上项目(No.82374112);中央民族大学科研能力提升计划(No.2023QNTS44);中央民族大学研究生科研实践项目(No.SZKY2023086)。

摘　　要：苦味受体/2型味觉受体(type 2 taste receptors,T2Rs)是一类G蛋白偶联受体,最初在味蕾细胞中被发现,现已证实在多种组织中表达并发挥功能。本文重点探讨了T2Rs在巨噬细胞中的表达水平、分布特征,以及T2Rs激动剂调节巨噬细胞的功能和作用机制,包括增强吞噬作用、诱导趋化性定向运动和调节巨噬细胞极化等,可能涉及NF-κB、PI3K/Akt和JAK/STAT等通路,但仍需更多数据支撑。T2Rs对巨噬细胞的调控作用虽已初显,但T2Rs亚型的作用规律尚不明晰。未来研究可从明确T2Rs亚型与巨噬细胞特定功能的对应关系、探究其调节巨噬细胞的具体分子机制、揭示在疾病进程中的详细机制等角度深入,为开发以T2Rs为靶点的新型药物奠定基础。Bitter taste receptors,also known as type 2 taste receptors(T2Rs),are found not only in the mouth's taste bud cells but also in various tissues and cells,including macrophages.Macrophages,known for their remarkable plasticity,play a crucial role in regulating innate immunity,managing inflammation,and orchestrating immune responses to antigens,pathogens,and environmental factors.Recently,the study of the expression and function of bitter taste receptors within macrophages has garnered significant interest.This review summarizes the expression levels and distribution characteristics of bitter taste receptors in macrophages and examines their effects on macrophage polarization,phagocytosis,and chemotaxis,as well as their potential molecular mechanisms.The purpose of this review is to provide insight and perspectives for research on the regulatory role of T2Rs in macrophage functions.

关 键 词：苦味受体 巨噬细胞 吞噬作用 趋化作用 极化 

分 类 号：R339.13[医药卫生—人体生理学] R967[医药卫生—基础医学] R285.5