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作 者:徐蕊 钱佳佳 阮聪 王祺茹 翟青[1,2,3] XU Rui;QIAN Jiajia;RUAN Cong;WANG Qiru;ZHAI Qing(Department of Pharmacy,Fudan University Shanghai Cancer Center Minhang Branch,Shanghai 200240,China;Department of Pharmacy,Fudan University Shanghai Cancer Center,Shanghai 200032,China;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China)
机构地区:[1]复旦大学附属肿瘤医院闵行院区药剂科,上海200240 [2]复旦大学附属肿瘤医院药剂科,上海200032 [3]复旦大学上海医学院肿瘤学系,上海200032
出 处:《世界临床药物》2024年第7期710-718,共9页World Clinical Drug
基 金:上海市闵行区卫生健康系统优秀青年药学人才计划(mwyjyx03);上海市闵行区自然科学研究课题(2022MHZ040);上海市闵行区健康科普能力提升英才专项计划(MHJKKPYC-2023-10)。
摘 要:新生血管的生成在多种实体肿瘤的生长、局部浸润以及远处转移中发挥关键作用。目前抗血管生成药物可为小分子多靶点、大分子单靶点和内源性泛靶点血管生成抑制剂3类。其中小分子抗血管生成抑制剂主要通过同时或序贯靶向多个生长因子/通路,从而抑制肿瘤血管新生,能有效抑制肿瘤细胞产生的耐药性。同时小分子抗血管生成抑制剂具有组织渗透性佳以及服用方便等优点,目前已被广泛用于多种实体肿瘤的联合治疗。该文对小分子抗血管生成酪氨酸激酶抑制剂的靶向治疗,以及其在多种实体瘤中的临床研究进展、安全性作一综述。Angiogenesis plays a key role in the growth,local invasion and distant metastasis of a variety of solid tumors.At present,anti-angiogenesis drugs can be divided into three types:small-molecule multi-target,macromolecule single-target and endogenous pan-target angiogenesis inhibitors.Among them,small molecule antiangiogenesis inhibitors mainly inhibit tumor angiogenesis by simultaneously or sequentially targeting multiple growth factors/pathways,and can effectively inhibit drug resistance generated by tumor cells.At the same time,small molecule anti-angiogenesis inhibitors have the advantages of good tissue permeability and convenient administration.At present,it has been widely used in the combination therapy of various solid tumors.This paper reviewed the targeted therapy of small molecule anti-angiogenic tyrosine kinase inhibitors and their clinical progress and safety in multiple solid tumors.
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