补虚养胃汤联合奥美拉唑对慢性萎缩性胃炎的疗效及对表皮生长因子、胃动素及可溶性白介素-2受体的影响  

Effects of tonifying deficiency and nourishing stomach decoction combined with omeprazole on chronic atrophic gastritis and on epidermal growth factor,motilin and soluble interleukin-2 receptor

作　　者：檀志娟 贾金英 张增建 TAN Zhijuan;JIA Jinying;ZHANG Zengjian(Department of Gastroenterology,Xingtai Hospital of Traditional Chinese Medicine,Xingtai 054001,Hebei Province,China)

机构地区：[1]邢台市中医医院内二科,河北邢台054001

出　　处：《世界临床药物》2024年第7期749-754,共6页World Clinical Drug

摘　　要：目的 探讨补虚养胃汤联合奥美拉唑(omeprazole,OME)治疗慢性萎缩性胃炎(chronic atrophic gastritis,CAG)的效果及对表皮生长因子(epidermal growth factor,EGF)、胃动素(motilin,MTL)及可溶性白介素-2受体(soluble interleukin-2receptor,s IL-2R)水平的影响。方法 选择2021年1月至2023年1月我院CAG患者109例,采用随机数表法分为试验组(OME+补虚养胃汤,n=55)和对照组(OME,n=54),予相应治疗后比较两组临床疗效、EGF、MTL、sIL-2R、胃泌素(gastrin,GAS)、胃蛋白酶原(pepsinogen,PG)、中医症状积分及不良反应发生情况。结果 治疗后,试验组总有效率高于对照组(87.27%vs 70.37%,P <0.05)。两组EGF、GAS以及PG水平较前均升高(P <0.05),且试验组较对照组升高更显著(P <0.05)。两组sIL-2R、MTL水平较前均降低(P <0.05),且试验组较对照组降低更显著(P <0.05)。两组胃脘疼痛、嗳气、胀闷及嘈杂泛酸评分较前下降明显(P <0.05),且试验组较对照组下降更显著(P <0.05)。治疗期间不良反应主要包括食欲不振、嗜睡以及恶心呕吐,但两组发生率无显著差异(P> 0.05)。结论 补虚养胃汤联合OME在CAG中有较佳疗效,可有效提高患者EGF水平,降低MTL、s IL-2R水平,改善临床症状,且安全性较佳。Objective To investigate the effect of tonifying deficiency and nourishing stomach decoction combined with omeprazole(OME)in the treatment of chronic atrophic gastritis(CAG)and its effect on epidermal growth factor(EGF),motilin(MTL)and soluble interleukin-2 receptor(sIL-2R)levels.Methods A total of 109 patients with CAG in our hospital from January 2021 to January 2023 were selected and divided into the experimental group(OME+tonifying deficiency and nourishing stomach decoction,n=55)and the control group(OME,n=54)by random number table method.The clinical efficacy,EGF,MTL,sIL-2R,gastrin(GAS),pepsinogen(PG),traditional Chinese medicine symptom score and occurrence of adverse reactions were compared between the two groups after corresponding treatment.Results After treatment,the total effective rate of experimental group was higher than that of control group(87.27%vs 70.37%,P<0.05).The levels of EGF,GAS and PG in both groups were higher than before(P<0.05),and the levels in experimental group were more significantly higher than those in control group(P<0.05).The levels of sIL-2R and MTL in both groups were lower than before(P<0.05), and the levels in experimental group were more significantly lower thanthose in control group(P<0.05). The scores of epigastric pain, belching, distension and noisy pantothenic acid in bothgroups were significantly decreased(P<0.05), and the scores in experimental group were more significantly decreasedthan those in control group(P<0.05). During treatment, the adverse reactions mainly included loss of appetite, lethargy,nausea and vomiting, but there was no significant difference in incidence between the two groups(P>0.05). ConclusionTonifying deficiency and nourishing stomach decoction combined with OME has better efficacy in CAG, which caneffectively improve EGF level, reduce MTL and sIL-2R levels, improve clinical symptoms and have good safety.

关 键 词：补虚养胃汤 奥美拉唑 慢性萎缩性胃炎 表皮生长因子 胃动素 可溶性白介素-2受体 

分 类 号：R259[医药卫生—中西医结合]