miR-155-5p对带状疱疹性神经痛慢性化的预测作用  

Predictive effect of miR-155-5p on chronicity in herpes zoster neuralgia

作　　者：沈倩倩[1] 王波[2] 杜忠举[2] 夏菊荣[2] SHEN Qianqian;WANG Bo;DU Zhongju;Xia Jurong(Department of Dermatological Surgery,Hangzhou Municipal Third People’s Hospital,Hangzhou,Zhejiang 310009,China;Department of Anesthesiology,Hangzhou Municipal Third People’s Hospital,Hangzhou,Zhejiang 310009,China)

机构地区：[1]杭州市第三人民医院皮肤外科,杭州310009 [2]杭州市第三人民医院麻醉科,杭州310009

出　　处：《重庆医学》2024年第16期2488-2491,共4页Chongqing Medical Journal

基　　金：浙江省自然科学基金杭州区域创新发展联合基金资助项目(LHZY24H090001);浙江省医药卫生科技计划项目(2024KY201)。

摘　　要：目的观察miR-155-5p在带状疱疹性神经痛慢性化过程中的表达及其预警作用。方法选择带状疱疹性神经痛患者88例(HZN组)和20例健康体检者(HA组),采用逆转录-实时荧光定量PCR(RT-qPCR)方法测量血清中miR-155-5p表达,患者随访3个月后仍有疼痛的为带状疱疹后神经痛(PHN组),疼痛消失为痊愈(RC组)。比较HZN组和HA组、PHN组和RC组miR-155-5p表达水平差异,计算受试者工作特征(ROC)曲线下面积(AUC)及95%CI评价miR-155-5p预测带状疱疹性神经痛慢性化的效能。结果与HA组比较,HZN组miR-155-5p表达水平明显上调,差异有统计学意义(P<0.05);与RC组比较,PHN组带状疱疹期miR-155-5p表达水平明显上调,差异有统计学意义(P<0.05);miR-155-5p预测带状疱疹性神经痛慢性化的AUC(95%CI)为0.878(0.808~0.948)。结论带状疱疹后神经痛患者带状疱疹期血清中miR-155-5p较痊愈患者表达水平明显上调,miR-155-5p可作为带状疱疹性神经痛慢性化的重要预测指标。Objective To observe the expression and forewarning effect of MiR-155-5p in the chronicity process of herpes zoster neuralgia(HZN).Methods A total of 88 patients with herpes zoster neuralgia(HZN group)and 20 healthy subjects undergoing physical examination(HA group)were selected.The expression level of serum miR-155-5p was measured by reverse transcription real-time fluorescence quantification polymerase chain reaction(RT-qPCR).The patients with pain after 3-month follow up served as herpes zoster neuralgia(PHN group)and those with pain disappearance served as the cure group(RC group).The expression levels of miR-155-5p were compared between the HZN group and HA group and between the PHN group and RC group.The area under receiver operating characteristic(ROC)curve(AUC)and 95%confidence interval(CI)were calculated for evaluating the efficiency of miR-155-5p in predicting the chronicity of HZN.Results Compared with the HA group,the expression level of miR-155-5p in the HZN group was significantly up-regulated,and the difference was statistically significant(P<0.05);compare with the RC group,the expression level of serum miR-155-5p in the PHN group was significantly up-regulated,and the difference was statistically significant(P<0.05);AUC of miR-155-5p for predicting the chronicity of HZN was 0.878(95%CI:0.808-0.948).Conclusion The expression level of serum miR-155-5p in herpes zoster period of the patients with PHN is significantly up-regulated compared with the cure patients and miR-155-5p could serve as an important predictive indicator of HZN chronicity.

关 键 词：miR-155-5p 带状疱疹性神经痛 慢性化 预警作用 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]