禽用活病毒载体疫苗的研究进展  

Research Progress on Live Viral-vectored Vaccines for Poultry

作　　者：王丽华 宋亚芬[1] 张兵 张乾义[1] 赵永达[2,3] 杨承槐 WANG Li-hua;SONG Ya-fen;ZHANG Bing;ZHANG Qian-yi;ZHAO Yong-da;YANG Cheng-huai(China Institute of Veterinary Drug Control,Beijing 100081,China;Qingdao Agricultural University,Qingdao,Shandong 266000,China;Qingdao BLSW.Co.,LTD,Qingdao,Shandong 266000,China)

机构地区：[1]中国兽医药品监察所(农业农村部兽药评审中心),北京100081 [2]青岛农业大学,山东青岛266000 [3]青岛博霖生物科技有限公司,山东青岛266000

出　　处：《中国兽药杂志》2024年第8期70-79,共10页Chinese Journal of Veterinary Drug

基　　金：国家重点研发计划“重要家禽疫苗效力评价用菌毒种筛选研究”(No.2022YFD1800602);山东省泰山产业领军人才项目(TS20220701);中央引导地方资金(YDZX2023123);山东省重大科技创新工程项目(2019 JZZY020601);青岛市产业培育计划科技惠民专项(23-2-8-xdny-14-nsh和24-2-8-xdny-4-nsh)。

摘　　要：疫苗接种是家禽疾病防控最有效的策略之一,随着分子生物学的发展,重组DNA技术被广泛用于许多新型家禽疫苗的构建和生产中。就近年来常用的火鸡疱疹病毒、鸭瘟病毒、传染性喉气管炎病毒、禽痘病毒、新城疫病毒等活病毒载体疫苗研究进展进行综述,分析其临床应用、优缺点等,为开发更加安全有效的家禽活病毒载体疫苗提供参考。Vaccination is one of the main strategies for controlling and preventing viral infection in poultry.With the development of molecular biology,recombinant DNA technology has been used to generate many novel poultry vaccines.The review discusses the results of a few studies about recombinant viral vector,the clinical application and advantages of vector vaccines based on herpesvirus of turkey,duck enteritis virus,infectious laryngotracheitis virus,fowl pox virus,newcastle disease virus were analyzed.It is particularly important to further study safer and more effective poultry recombinant vector vaccines.

关 键 词：家禽 病毒载体 疫苗 

分 类 号：S859.65[农业科学—临床兽医学]