针对蜂毒变应原检测的研究进展  

Research Progress in Detection of Bee Venom Allergens

作　　者：赵慧敏 李俊达 崔乐 关凯 ZHAO Huimin;LI Junda;CUI Le;GUAN Kai(Department of Allergy,PUMC Hospital,CAMS and PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院变态反应(过敏)科,北京100730

出　　处：《中国医学科学院学报》2024年第4期565-574,共10页Acta Academiae Medicinae Sinicae

基　　金：中央高水平医院临床科研专项(2022-PUMCH-B-088)。

摘　　要：对于膜翅目毒素过敏人群,膜翅目昆虫蜇刺是其不可忽视的危险因素。我国现有的诊断工具无法提供准确的信息来明确致敏昆虫,从而影响临床的诊断和治疗。蜜蜂为常见的膜翅目昆虫,分布地域广、数量多,且其毒素成分复杂,因此国内外研究者已针对蜜蜂毒素主要变应原开展了相关重组变应原方案工作,这为变应原检测提供了一定的理论基础。变应原组分诊断技术的发展可实现准确检测蜂毒变应原,这将为蜜蜂蜂毒过敏患者提供一套全新的临床诊断和治疗方案。Hymenopteran insect stings are a risk factor that cannot be ignored for the people allergic to hymenopteran venoms.In China,the current diagnostic tools cannot provide accurate information to identify sensitized insects,thus affecting clinical diagnosis and treatment.Honeybee is a common hymenopteran insect.Due to its wide distribution,large number,and complex venom composition,researchers have carried out recombination schemes for the main allergens of honeybee venom,laying a theoretical foundation for the detection of allergens.The development of diagnostic technologies for allergen components can accurately detect bee venom allergens,providing a new set of clinical diagnosis and treatment schemes for the population allergic to bee venom.

关 键 词：膜翅目昆虫蜇刺 蜜蜂毒素 重组变应原 变应原检测 变应原组分诊断技术 

分 类 号：R593.1[医药卫生—内科学] Q819[医药卫生—临床医学]