补体受体免疫球蛋白超家族分子在调节肝脏免疫反应中的研究进展  

Research Progress in Complement Receptor of the Immunoglobulin Superfamily in Regulating Liver Immunity

作　　者：杨树森 李京涛 闫曙光[1] 焦俊喆 YANG Shusen;LI Jingtao;YAN Shuguang;JIAO Junzhe(Basic Medical College of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,China;Department of Hepatology,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712000,China)

机构地区：[1]陕西中医药大学基础医学院,陕西咸阳712046 [2]陕西中医药大学附属医院肝病科,陕西咸阳712000

出　　处：《中国医学科学院学报》2024年第4期603-609,共7页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(82174330)。

摘　　要：库普弗细胞(KC)是肝脏免疫细胞的重要组成部分,其对于维持组织稳态和应对肝损伤的快速反应至关重要。补体受体免疫球蛋白超家族分子(CRIg)是KC膜上的一种受体蛋白,其既能以补体结合的方式捕获流经肝脏血液中的病原体,也可以通过调节肝脏内的免疫细胞介导肝脏免疫反应。近年来CRIg的研究进一步证实了其在调节肝脏免疫中的关键地位,本文综述了CRIg的主要作用方式以及其在调节肝脏免疫中的新进展。Kupffer cells(KC),an important subset of immune cells in the liver,are essential for maintaining tissue homeostasis and responding quickly to liver damage.The complement receptor of the immunoglobulin superfamily(CRIg)is a receptor protein on the KC membrane.CRIg can not only capture pathogens in the blood flowing through the liver by complement binding but also mediate immune responses by regulating immune cells in the liver.Recent studies have confirmed the role of CRIg in regulating liver immunity.This article reviews the main modes of action of CRIg and the research progress of CRIg in regulating liver immunity.

关 键 词：补体受体免疫球蛋白超家族分子 库普弗细胞 肝脏免疫 病原体 

分 类 号：R392.32[医药卫生—免疫学]