鸡胰岛素信号通路的研究进展  

Advances in the Study of Chicken Insulin Signaling Pathway

作　　者：娄明 罗昊玉 牟芳 李辉 王宁[1,2,3] LOU Ming;LUO Haoyu;MU Fang;LI Hui;WANG Ning(Key Laboratory of Chicken Genetics and Breeding of Ministry of Agriculture and Rural Affairs,Harbin 150030,China;Key Laboratory of Animal Genetics,Breeding and Reproduction,Education Department of Heilongjiang Province,Harbin 150030,China;College of Animal Science and Technology,Northeast Agricultural University,Harbin 150030,China)

机构地区：[1]农业农村部鸡遗传育种重点实验室,哈尔滨150030 [2]黑龙江省普通高等学校动物遗传育种与繁殖重点实验室,哈尔滨150030 [3]东北农业大学动物科学技术学院,哈尔滨150030

出　　处：《畜牧兽医学报》2024年第8期3288-3296,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(U23A20230)

摘　　要：胰岛素作为机体所必需的激素,在动物糖脂代谢、蛋白合成、生长发育、性状形成等生理过程中发挥重要作用。鸡存在天然的胰岛素抵抗,但其发生机制尚不清楚。本文综述了鸡肝脏、肌肉和脂肪组织胰岛素通路的研究进展,提出了鸡胰岛素信号通路和胰岛素抵抗的未来研究方向,以期为深入探究人类胰岛素抵抗以及鸡肉品质遗传改良提供新思路。Insulin is an essential hormone and plays crucial roles in a variety of biological processes including glucose and lipid metabolism,protein synthesis,growth,development,and trait formation.Chickens have natural insulin resistance,but the cause of chicken insulin resistance is still unknown.This review summarizes the research progress on the insulin signaling pathway in chicken liver,muscle and adipose tissue,and then proposes future research directions in chicken insulin signaling pathway and insulin resistance,with a view to providing new ideas for in-depth exploration of human insulin resistance and genetic improvement of chicken meat quality.

关 键 词：鸡 胰岛素信号通路 胰岛素抵抗 肝脏 肌肉 脂肪组织 

分 类 号：S831.2[农业科学—畜牧学]