嵌杯病毒主要衣壳蛋白的研究进展  

Progress in Research of Major Capsid Protein of Calicivirus

作　　者：谈晓梅 徐彦召[2] 刘光清[1] 孟春春[1] TAN Xiaomei;XU Yanzhao;LIU Guangqing;MENG Chunchun(Team for Companion Animal Biosafety and Prevention Technology,Shanghai Institute of Veterinary Medicine,CAAS Chinese Academy of Agricultural Sciences,Shanghai 200241,China;Henan Institute of Science and Technology,Xinxiang 453003,China)

机构地区：[1]中国农业科学院上海兽医研究所伴侣动物生物安全与防控技术团队,上海200241 [2]河南科技学院,新乡453003

出　　处：《畜牧兽医学报》2024年第8期3354-3361,共8页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：“十四五”重点研发计划(2022YFD1800100);国家自然科学基金面上项目(32272982);上海市自然科学基金(23ZR1477100)。

摘　　要：嵌杯病毒(calicivirus)是无囊膜的单股正链RNA病毒,具有广泛的宿主范围因而严重威胁着人和许多其他脊椎动物的健康。由于该病毒种属流行株多变、极易传播且呈现区域性感染,致使全球范围内因杯状病毒引起的公共卫生疾病频繁暴发,近年来,其感染发病率呈明显增加的趋势。不同属成员虽然感染不同种类的宿主,但其主要衣壳蛋白的结构类似。嵌杯病毒主要衣壳蛋白中含有免疫原性关键区域,能与宿主受体结合并可能介导感染过程,且氨基酸相关的免疫原性及受体结合位点的变异是公认的病毒进化的驱动力。本文就嵌杯病毒主要衣壳蛋白的基因组结构、免疫原性、受体结合情况以及遗传演化规律等方面的研究进展进行综述,以期为后续科学研究以及该病的有效防控提供参考。Calicivirus is a single-stranded positive-sense RNA and non-enveloped viruse,which has a wide host range and thus seriously threaten the health of humans and many other vertebrates.Due to the variety of virus species and epidemic strains,easy transmission and regional infection,public health diseases caused by calicivirus frequently broke out worldwide,and its incidence of infection has increased significantly in recent years.Although different genera infect different types of hosts,their main capsid proteins have similar structures.The major capsid protein of calicivirus contains critical regions of immunogenicity,which can bind to host receptors and may mediate the infection process.Moreover,amino acid-related immunogenicity and variation of receptor binding sites are recognized as driving forces of viral evolution.In this paper,we reviewed the progress of research on the genomic structure,immunogenicity,receptor binding and genetic evolution of the major capsid proteins of calicivirus,with a view to providing references for subsequent scientific research and effective prevention and control of related diseases.

关 键 词：嵌杯病毒 主要衣壳蛋白 结构 功能 

分 类 号：S852.659.6[农业科学—基础兽医学]