锰纳米佐剂的制备及生物学效应  

Preparation of Nano-manganese and Its Biological Effects

作　　者：王梦迪 王恒[1] 鲁秀香 王昱旻 樊文杰[1] 姚晨 刘鹏翔 马延杰 杨国宇[1,2] WANG Mengdi;WANG Heng;LU Xiuxiang;WANG Yumin;FAN Wenjie;YAO Chen;LIU Pengxiang;MA Yanjie;YANG Guoyu;WANG Jiang(Key Open Laboratory of Animal Biochemistry and Nutrition,Ministry of Agriculture and Rural Affairs,Henan Agricultural University,Zhengzhou 450046,China;College of Food and Biotechnology,Henan University of Animal Husbandry Economics,Zhengzhou 450046,China)

机构地区：[1]河南农业大学农业农村部动物生化与营养重点开放实验室,郑州450046 [2]河南牧业经济学院食品与生物工程学院,郑州450046

出　　处：《畜牧兽医学报》2024年第8期3374-3382,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：河南省科技攻关(232102310381);河南牧业经济学院博士科研启动资金资助(2022HNUAHEDF033);国家重点研发计划项目子课题(2021YFD1301201)。

摘　　要：锰作为生命活动中重要微量元素参与了多种生理过程。对于能量代谢、神经系统发育和免疫系统正常运行至关重要。与可溶性锰离子相比,纳米锰可维持锰离子在注射部位持续释放,以诱导局部的免疫应答,并增强树突状细胞(dendritic cells,DCs)对抗原的摄取,促进DCs在体内活化与成熟。本文从纳米锰作用机制、制备方法、功能表征、纳米佐剂存在的问题和解决策略等方面进行综述,重点介绍了纳米锰作为疫苗佐剂的应用,并提出存在问题及解决策略。Manganese is an important trace element that participates in various physiological processes,including skeletal,reproductive,energy metabolism,and normal functioning of the nervous and immune systems.Compared with soluble manganese ions,nano-manganese can maintain the continuous release of manganese ions at the injection site,induce local immune responses,and enhance the cellular uptake of antigens by dendritic cells(DCs),promoting the activation and maturation of DCs in the body.This article reviews the relevant issues of nano-manganese from the perspectives of their mechanism of action,preparation methods,functional characterization,problems with nano adjuvants,and solutions.The application of nano-manganese as vaccine adjuvants was emphasized and the problems and solutions of nano-manganese were proposed.

关 键 词：纳米锰 疫苗佐剂 研究进展 

分 类 号：S852.4[农业科学—基础兽医学]