肌少症与废用性肌萎缩  

Sarcopenia and disuse muscular atrophy

作　　者：刘震超 王猛[2] 郭思晗 雷天翔 王云[4] LIU Zhenchao;WANG Meng;GUO Sihan;LEI Tianxiang;WANG Yun(Integrated Medicine Center,Qingdao University,Qingdao 260021,China;Pharmacy Department,Linyi People’s Hospital,Linyi 276000,China;Food Hygiene and Nutrition,Shandong University of Traditional Chinese Medicine,Jinan 250000,China;Health Management Center,Linyi People’s Hospital,Linyi 276000,China)

机构地区：[1]青岛大学医学部中西医结合中心,山东青岛260021 [2]临沂市人民医院药剂科,山东临沂276000 [3]山东中医药大学,山东济南250000 [4]临沂市人民医院健康管理中心,山东临沂276000

出　　处：《中国骨质疏松杂志》2024年第8期1219-1223,共5页Chinese Journal of Osteoporosis

基　　金：山东省自然科学基金(ZR2018HL041)。

摘　　要：本研究旨在比较肌少症和废用性肌萎缩这两种常见的肌萎缩现象。肌少症与废用性肌萎缩均涉及肌肉退化,但两者并不相同。肌少症主要由于年龄增长或慢性疾病导致的肌纤维减少和快肌纤维萎缩,而废用性肌萎缩则是由于肌肉活动量不足引起的肌纤维横截面积减小和慢肌纤维退化。两者在发生机制上虽然具有一定的相近之处,但是最终的生理改变各不相同。另外,目前对于肌少症和废用性肌萎缩的区分和界定仍存在一些争议。未来的研究需要更深入地探索肌纤维类型和功能的变化,进一步区分二者的差异,有助于寻找更有效的预防和治疗策略。This research aims to compare sarcopenia and disuse muscular atrophy,two common phenomena of muscle wasting.While both sarcopenia and disuse muscular atrophy involve muscle degeneration,but the two are not the same.Sarcopenia is characterized by a reduction in muscle fibers and fast-twitch fiber atrophy caused by aging or chronic diseases,while disuse muscular atrophy is characterized by a decrease in muscle fiber cross-sectional area and slow-twitch fiber degeneration due to inadequate muscle activity.Although there are some similarities in the underlying mechanisms of these two conditions,the ultimate physiological changes are different Furthermore,there is still some controversy regarding the differentiation and definition of sarcopenia and disuse muscular atrophy.Future research needs to further explore changes in muscle fiber types and functions in order to better differentiate between the two and to develop more effective prevention and treatment strategies.

关 键 词：肌少症 废用性肌萎缩 肌纤维 

分 类 号：R1[医药卫生—公共卫生与预防医学]