主动脉瓣狭窄合并心脏淀粉样变的研究进展  

Concomitant Aortic Stenosis and Cardiac Amyloidosis

作　　者：龙颉婧 邱悦[1] 马春燕[1] 陈昕[1] LONG Xiejing;QIU Yue;MA Chunyan;CHEN Xin(Department of Cardiovascular Ultrasound,The First Hospital of China Medical University,Clinical Medical Research Center of Imaging in Liaoning Province,Shenyang 110001,Liaoning,China)

机构地区：[1]中国医科大学附属第一医院心血管超声科、辽宁省影像医学临床医学研究中心,辽宁沈阳110001

出　　处：《心血管病学进展》2024年第8期697-701,共5页Advances in Cardiovascular Diseases

基　　金：辽宁省教育厅基本科研项目(LJKMZ20221139)。

摘　　要：主动脉瓣狭窄(AS)合并心脏淀粉样变(CA)在老年群体中并不罕见。由于AS和CA有相似的临床、影像和实验室检查表现使其诊断具有挑战性,而AS-CA患者较单独AS患者预后更差,延迟诊断将增加死亡风险。随着诊断成像技术发展,多模态、多参数综合评估方法和有效药物的研发有助于AS-CA的早期诊断和治疗,从而有效改善患者预后。现总结AS-CA的流行病学、病理生理学、发病机制、诊断和治疗的研究进展。The prevalence of the coexistence of aortic stenosis(AS)and cardiac amyloidosis(CA)is not uncommon in elderly.The diagnosis of AS-CA is challenging due to the similar clinical,imaging,and laboratory features between the two diseases.However,patients with AS-CA have a worse prognosis than patients with AS alone,and delayed diagnosis increases the risk of death.With the development of imaging techniques,The multimodal and multiparameter comprehensive assessment is conducive to a diagnosis of early AS-CA at present,as to formulate personalized treatment and improve patient outcomes.This article reviews the recent progress in the epidemiology,pathophysiology,pathogenesis,diagnosis,and treatment of AS-CA.

关 键 词：主动脉瓣狭窄 心脏淀粉样变 多模态影像 

分 类 号：R542.5[医药卫生—心血管疾病] R541[医药卫生—内科学]