琥珀酸在心肌缺血再灌注损伤中的研究进展  

Succinic Acid and Myocardial Ischemia-Reperfusion Injury

作　　者：热伊莱•开赛尔 谢翔[1] Reyilai•Kaisaier;XIE Xiang(Department of Heat Center,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)

机构地区：[1]新疆医科大学第一附属医院心脏中心,新疆乌鲁木齐830054

出　　处：《心血管病学进展》2024年第8期722-726,共5页Advances in Cardiovascular Diseases

基　　金：新疆维吾尔自治区重点研发任务专项(2022B0322-5)。

摘　　要：心肌缺血再灌注损伤(MIRI)是指缺血心肌恢复正常灌注后,细胞或组织的结构损伤和功能障碍反而呈进行性加重的病理生理现象,可引发恶性心律失常、心力衰竭甚至猝死。因此,降低再灌注对缺血心肌的损害已成为亟待解决的问题。琥珀酸是三羧酸循环的中间代谢产物,最近研究发现,心肌缺血组织中琥珀酸含量显著增加,并在再灌注过程中可通过氧化应激、能量代谢障碍、免疫炎症等机制参与MIRI的发生与发展。琥珀酸作为新型循环标志物有望为MIRI的防治提供新思路。现对琥珀酸在MIRI中的作用机制及靶向治疗研究进展进行综述,以期对预防MIRI有借鉴意义。Myocardial ischemia-reperfusion injury(MIRI)is a pathophysiological phenomenon in which the structural damage and dysfunction of cells and tissues are progressively aggravated after ischemic myocardium is restored to normal perfusion,which can lead to malignant arrhythmia,heart failure and even sudden death.Therefore,reducing the damage of reperfusion to ischemic myocardium has become an urgent problem.Succinic acid is an intermediate metabolite of the tricarboxylic acid cycle,and recent studies have found that the succinic acid concentration in myocardial ischemic tissues is significantly increased,and involves oxidative stress,impaired energy metabolism,immunoinflammation in the process of MIRI.In this paper,the mechanism of succinic acid in MIRI and the progress of targeted therapeutic research are summarized,in order to be useful for the prevention of MIRI.

关 键 词：琥珀酸 心肌缺血再灌注损伤 治疗靶点 

分 类 号：R542.2[医药卫生—心血管疾病]