残余胆固醇在动脉粥样硬化性心血管疾病中的作用机制研究进展  

Action Mechanism of Remnant Cholesterol and Atherosclerotic Cardiovascular Disease

作　　者：杜孝亮 徐静 李樊丹 杨浩[1] 吕湛[1] DU Xiaoliang;XU Jing;LI Fandan;YANG Hao;LYU Zhan(Department of Cardiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院心血管内科,四川南充637000

出　　处：《心血管病学进展》2024年第8期732-736,752,共6页Advances in Cardiovascular Diseases

基　　金：川北医学院校级科研发展基金(CBY22-QNA23)。

摘　　要：动脉粥样硬化性心血管疾病(ASCVD)已成为全球公共卫生面临的最大威胁之一,也是导致死亡的主要原因。低密度脂蛋白胆固醇(LDL-C)是动脉粥样硬化疾病一级和二级预防的主要目标。然而将LDL-C控制到推荐浓度,仍存在显著的残余心血管风险。越来越多的研究发现,残余胆固醇(RC)的水平与残余心血管风险密切相关。RC在ASCVD中的作用机制尚不明确,现重点介绍目前研究发现的RC作用机制,这些机制主要包括激活炎症、参与氧化应激、促进易损斑块形成、加速血栓形成和引起胰岛素抵抗等。此外,还讨论了未来可能用于控制RC的药物。Atherosclerotic cardiovascular disease(ASCVD)has become one of the greatest threats to global public health and the leading cause of death.Low-density lipoprotein cholesterol(LDL-C)is the vital target for primary and secondary prevention of atherosclerotic diseases.Nevertheless,patients with recommended concentrations in LDL-C still have a considerable residual risk of cardiovascular adverse events.Accumulating studies suggest that levels of remnant cholesterol(RC)were associated with residual risk of cardiovascular adverse events.The mechanisms underlying the effects of RC on ASCVD remain unclear.This article highlights the action mechanisms of RC that have been identified in current studies,which include activation of inflammation,involvement in oxidative stress,promotion of vulnerable plaque formation,acceleration of thrombosis,and insulin resistance.In addition,potential future drugs for RC control are discussed.

关 键 词：动脉粥样硬化 心血管疾病 残余胆固醇 作用机制 药物治疗 

分 类 号：R543.5[医药卫生—心血管疾病]