微RNA在冠状动脉微栓塞后心肌损伤的研究进展  

MicroRNA-Mediated Regulation of Cardiomyocyte Injury FollowingCoronary Microembolisation

作　　者：李蓝鸽 郑雅璇 吕婷婷 李锟 孔令云 周博达 刘芳[1] 张萍[1] 薛亚军 LI Lan’ge;ZHENG Yaxuan;LYU Tingting;LI Kun;KONG Lingyun;ZHOU Boda;LIU Fang;ZHANG Ping;XUE Yajun(Beijing Tsinghua Changgung Hospital Cardiovascular Center,Affiliated with Tsinghua University,Beijing 102218,China;School of Medicine,Tsinghua University,Beijing 100083,China)

机构地区：[1]清华大学附属北京清华长庚医院心血管中心,北京102218 [2]清华大学医学院,北京100083

出　　处：《心血管病学进展》2024年第8期747-752,共6页Advances in Cardiovascular Diseases

基　　金：北京市属医院科研培育计划(PX20210902)。

摘　　要：冠状动脉微栓塞(CME)多发生于急性冠脉综合征患者,因手术相关的动脉粥样硬化斑块破裂引发,可导致心律失常、冠状动脉血流储备减少以及心脏收缩功能障碍。CME后常规扩张冠状动脉、抗血小板和直接抽吸血栓的临床疗效不理想。研究发现,微RNA(miRNA)特异结合炎症反应、凋亡、自噬相关信使RNA的3’-UTR,最终影响CME预后。深入研究miRNA在CME发生和发展中的作用,不仅可以进一步了解CME后不良预后机制,还有助于为其药物治疗寻找新的靶点。Coronary microembolization(CME)occurs in patients with acute coronary syndrome and is primarily caused by atherosclerotic plaque rupture associated with surgery.CME can lead to arrhythmias,reduced coronary blood flow reserve,and cardiac systolic dysfunction.The clinical efficacies of conventional coronary artery dilation,antiplatelet agents,and direct thrombus aspiration after CME are not satisfactory.Studies have found that microRNA(miRNA)specifically binds to the 3’-UTR of inflammatory response,apoptosis,and autophagy-related messenger RNA,and ultimately affect the prognosis of CME.In-depth studies of the role of miRNA in the occurrence and development of CME can not only further understand the mechanism of poor prognosis after CME,but also help to find new targets for its drug treatment.

关 键 词：冠状动脉微栓塞 微RNA 炎症反应 凋亡 自噬 

分 类 号：R541.4[医药卫生—心血管疾病]