氯己定与抗生素耐药性相关性的研究进展  

A review on the association between chlorhexidine and antibiotic resistance

作　　者：任静宜 王美娟 周文娟 柳忠豪 Ren Jingyi;Wang Meijuan;Zhou Wenjuan;Liu Zhonghao(Yantai Stomatological Hospital Affiliated to Binzhou Medical University,Department of implantology,Yantai 264008)

机构地区：[1]滨州医学院附属烟台市口腔医院种植科,烟台264008

出　　处：《中国抗生素杂志》2024年第7期779-785,共7页Chinese Journal of Antibiotics

基　　金：烟台市科技创新发展计划(No.2020YT06001061)。

摘　　要：抗生素耐药性是全球人类公共健康领域的巨大危机,影响生命安全并给社会带来巨大的经济负担。氯己定(chlorhexidine,CHX)是临床最为常用的消毒剂之一。目前已有大量研究发现,CHX应用与抗生素耐药性密切相关。一方面,已有研究证实CHX可诱导多种重要的院内感染病原菌发生抗生素交叉耐药,甚至出现对最后一线抗生素的耐药性;另一方面,CHX与抗生素可能存在共耐药。主动外排泵的过度表达及细胞膜的相关改变是CHX与抗生素耐药性相关性中的重要机制。然而,CHX被广泛无限制地应用于临床领域,其潜在风险被严重低估。因此,本文将回顾CHX与抗生素耐药性的相关性及其相关机制,以提高CHX临床应用的警示。Antibiotic resistance is a global public health crisis affecting human beings that enormously threatens lives and burdens society and the economy.Chlorhexidine(CHX)is one of the most widely applied antiseptic agents in clinical practice.Currently,growing research has revealed a close association between CHX and antibiotic resistance.On the one hand,it has been demonstrated that CHX could induce antibiotic cross-resistance,even including resistance to the last-sort antibiotic in several important pathogens causing nosocomial infections.On the other hand,the co-resistance between CHX and antibiotics might exist.The overexpression of efflux pumps and alterations of cell membranes are vital mechanisms accounting for the association between CHX and antibiotic resistance.However,the potential risk of the extensive utilization of CHX in clinical practice has been far underestimated.Thus,this paper reviewed the evidence on the association between CHX and antibiotic resistance and linking mechanisms to raise awareness of its clinical application.

关 键 词：CHX 抗生素 交叉耐药 共耐药 主动外排泵 

分 类 号：R978.1[医药卫生—药品]