心脏彩超指标联合血清HSP27、miR-30a水平与老年肺源性心脏病患者预后的相关性及其预测价值  

Correlation and predictive value of cardiac color ultrasound indexes combined with serum HSP27 and miR-30a levels in elderly patients with pulmonary heart disease

作　　者：喻晶晶 Yu Jing-jing(Department of Special Inspection,Xinyang 154th Hospital,Xinyang 464000,Henan,China)

机构地区：[1]信阳一五四医院特检科,河南信阳464000

出　　处：《四川生理科学杂志》2024年第8期1798-1800,1885,共4页

摘　　要：目的:分析不同预后老年肺源性心脏病患者心脏彩超指标与血清热休克蛋白27(Heat shock protein 27,HSP27)、微小核糖核苷酸-30a(microRNA-30a,miR-30a)水平的相关性,并分析其预测价值。方法:选取本院2021年4月至2023年6月期间收治的81例老年肺源性心脏病患者纳入研究对象,根据患者的预后情况分为预后良好组、预后不良组。另选取同期81例健康体检者为对照组。对比三组入院时及研究组治疗14 d后血清HSP27、miR-30a及Tei指数、肺动脉收缩压(Pulmonary artery systolic pressure,PASP)水平,并分析其相关性及影响患者发生预后不良的危险因素和预测价值。结果:预后不良组血清HSP27、miR-30a及Tei指数、PASA水平相较预后良好组、对照组,均显著升高。血清HSP27、miR-30a与Tei指数、PASA均呈正相关(P<0.05)。入院时血清HSP27、miR-30a及Tei指数、PASA存在显著关联性(P<0.05)。血清HSP27、miR-30a及Tei指数、PASA水平联合预测患者发生预后不良的AUC均高于各指标单独预测。结论:老年肺源性心脏病患者心脏彩超指标与血清HSP27、miR-30a密切相关,三项联合检测对老年肺源性心脏病患发生预后不良的预测价值较高。Objective:To analyze the correlation between cardiac color ultrasound indexes and serum heat shock protein 27(HSP27)and micrornA-30A(miR-30a)levels in elderly patients with pulmonary heart disease with different prognosis,and to analyze its predictive value.Methods:Eighty-one elderly patients with pulmonary heart disease admitted to our hospital from April 2021 to June 2023 were selected as study objects,and they were divided into good prognosis group and poor prognosis group according to their prognosis.Another 81 cases of healthy physical examination during the same period were selected as the control group.The levels of serum HSP27,miR-30a and Tei index,pulmonary artery systolic pressure(PASP)were compared among the three groups at the time of admission and after 14 days of treatment,and correlation,risk factors affecting the occurrence of patients with a poor prognosis and their predictive value were analyzed.Results:The levels of serum HSP27,miR-30a,Tei index and PASA in poor prognosis group were significantly higher than those in good prognosis group and control group(P<0.05).The levels of serum HSP27,miR-30a,Tei index and PASA in the poor prognosis group were higher than those in the good prognosis group at 14 days after treatment(P<0.05).Serum HSP27 and miR-30a were positively correlated with Tei index and PASA(P<0.05).Serum HSP27,miR-30a,Tei index and PASA at admission were risk factors for poor prognosis(P<0.05).The Area under the curve(AUC)of serum HSP27,miR-30a combined with Tei index and PASA levels was higher than that of single index.Conclusion:In elderly patients with pulmonary heart disease,Color Doppler ultrasound indexes are closely related to serum HSP27 and miR-30a;and the combined detection of these factors has high predictive value for poor prognosis.

关 键 词：心脏彩超指标 HSP27 miR-30a 老年肺源性心脏病 预后 

分 类 号：R445.1[医药卫生—影像医学与核医学] R541.5[医药卫生—诊断学]