乙肝孕妇HBV-DNA载量检测在母婴传播筛查中的应用效果评估  

Analysis of the application value of HBV DNA load detection in hepatitis B pregnant women in mother to child transmission

作　　者：谢晓玲 Xie Xiao-ling(Department of Laboratory,Yudu Maternal and Child Health Hospital,Ganzhou 342300,Jiangxi,China)

机构地区：[1]于都县妇幼保健院检验科,江西赣州342300

出　　处：《四川生理科学杂志》2024年第8期1864-1866,共3页

摘　　要：目的:分析乙肝孕妇乙型肝炎病毒(hepatitis B virus,HBV)脱氧核糖核酸(Deoxyribonucleic acid,DNA)载量检测在母婴传播筛查中的应用效果评估。方法:选取2021年1月至2022年1月乙肝孕妇100例进入研究,根据孕妇乙肝两对半定性检测结果分为大三阳组,小三阳组和其他组,比较各组间孕妇新生儿脐带血HBV-DNA载量检测结果及1年后新生儿HBV DNA阳性率;比较不同HBV-DNA载量孕妇新生儿脐带血HBV-DNA载量检测结果。结果:100例孕妇中大三阳46例(46.00%),小三阳32例(32.00%),其他22例(22.00%)。100例孕妇中新生儿脐带血HBV-DNA阳性共14例,宫内感染发生率14.00%。大三阳组新生儿脐带血HBV-DNA阳性率显著高于小三阳组和其他组(P<0.05);三组间1年后新生儿HBV DNA阳性率无显著性差异(P>0.05);100例孕妇中HBV-DNA载量≥10^(5)37例(37.00%),10^(3)~10^(5)44例(44.00%)和<10^(3)19例(19.00%)。HBV-DNA载量≥10^(5)中新生儿脐带血HBV-DNA阳性率显著高于10^(3)~10^(5)和<10^(3)(P<0.05);HBV-DNA载量≥10^(5)中平均新生儿脐带血HBV-DNA log病毒载量显著高于10^(3)~10^(5)(P<0.05)。结论:乙肝孕妇HBV-DNA载量检测对母婴传播具有重要意义,该检测有助于评估孕妇感染程度、预测婴儿感染风险,并监测治疗效果,值得推广应用。Objective:To analyze the application value of hepatitis B virus(HBV)Deoxyribonucleic acid(DNA)load detection in mother to child transmission in pregnant women with hepatitis B.Methods:100 pregnant women with hepatitis B from January 2021 to January 2022 were selected for the study.According to the results of two pairs of semi qualitative tests of hepatitis B B in pregnant women,they were divided into large three positive groups,small three positive groups,and other groups.The detection results of HBV DNA load in umbilical cord blood of pregnant women in each group and the positive rate of HBV DNA in newborns after one year were compared;Compare the HBV-DNA load test results of umbilical cord blood from pregnant women and newborns with different HBV-DNA loads.Results:Among the 100 pregnant women,there were 46 cases(46.00%)with high triple positive,32 cases(32.00%)with low triple positive,and 22 cases(22.00%)with low triple positive.Among 100 pregnant women,14 newborns had positive HBV-DNA in umbilical cord blood,and the incidence of intrauterine infection was 14.00%.The positive rate of HBV-DNA in umbilical cord blood of newborns in the large three positive group was significantly higher than that in the small three positive group and other groups(P<0.05);There was no significant difference in the positive rate of HBV DNA in newborns among the three groups after 1 year(P>0.05);Among 100 pregnant women,HBV-DNA load≥10^(5)37 cases(37.00%),10^(3)-10^(5)44 cases(44.00%),and<10^(3)19 cases(19.00%).The positive rate of HBV-DNA in umbilical cord blood of newborns with a HBV-DNA load≥10^(5)was significantly higher than that of newborns with a HBV-DNA load of 10^(3)-10^(5)and<10^(3)(P<0.05);The average HBV-DNAlog virus load in umbilical cord blood of newborns with HBV-DNA load≥10^(5)was significantly higher than that of 10^(3)-10^(5)(P<0.05).Conclusion:The detection of HBV DNA load in pregnant women with hepatitis B is of great significance for mother to child transmission.The detection is helpful to evaluate the inf

关 键 词：乙型肝炎 孕妇 母婴传播 乙型肝炎病毒 

分 类 号：R512.62[医药卫生—内科学]