重组人脑利钠肽辅助无创正压通气治疗急性左心衰竭的疗效观察  

Curative effect of non-invasive positive pressure ventilation assisted with recombinant human brain natriuretic peptide in acute left heart failure

作　　者：刘富秀 冯新辉 Liu Fu-xiu;Feng Xin-hui(Department of Pharmacy,Xinfeng Hospital of Traditional Chinese Medicine,Ganzhou 341600,Jiangxi,China;Department of Critical Care Medicine,Xinfeng Hospital of Traditional Chinese Medicine,Ganzhou 341600,Jiangxi,China)

机构地区：[1]信丰县中医院药剂科,江西赣州341600 [2]信丰县中医院重症医学科,江西赣州341600

出　　处：《四川生理科学杂志》2024年第8期1870-1872,共3页

摘　　要：目的:研究重组人脑利钠肽辅助无创正压通气(Non-invasive positive pressure ventilation,NIPPV)治疗急性左心衰竭的临床治疗效果。方法:回顾性选取2020年6月至2023年6月间本院收治的60名急性左心衰竭患者作为研究对象,采用倾向性匹配法校正混杂因素影响后,按照1:1将选取联合组与NIPPV组各30例。联合组以重组人脑利钠肽辅助无创正压通气治疗,NIPPV组以无创正压通气治疗作为对照。比较联合组与NIPPV组用药7 d前后临床疗效、N末端脑利钠肽前体水平、氧合指数、左室舒张末期内径、左室射血分数;对比联合组与NIPPV组24 h尿量、撤机时间与住院时间。结果:治疗后,联合组治疗效果显著优于NIPPV组,差异存在统计学意义(P<0.05);联合组住院时间与撤机时间均较NIPPV组减少,差异存在统计学意义(P<0.05)。与治疗前相比,各治疗组的氧合指数与左室射血分数均明显升高(P<0.05),其中联合组更为显著(P<0.05);各治疗组的N末端脑利钠肽前体水平、左室舒张末期内径均明显降低(P<0.05),其中联合组更为显著(P<0.05);各治疗组的24 h尿量均明显增加(P<0.05),其中联合组更为显著(P<0.05);结论:重组人脑利钠肽辅助NIPPV治疗急性左心衰竭具有良好的疗效,可有效改善急性左心衰竭患者血氧含量与左心室泵血功能,促进患者恢复。Objective:To study the clinical curative effect of non-invasive positive pressure ventilation(NIPPV)assisted with recombinant human brain natriuretic peptide(rhBNP)in acute left heart failure(ALHF).Methods:A total of 60 patients with ALHF admitted to the hospital were retrospectively enrolled as the research objects between June 2020 and June 2023.After correcting the influences of confounding factors,they were divided into combination group(NIPPV assisted with rhBNP)and NIPPV group(NIPPV)by propensity matching method,30 cases in each group.The clinical curative effect,N-terminal pro brain natriuretic peptide(NT-proBNP),oxygenation index,left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)before and after 7 days of medication,24 hours urine volume,weaning time and length of hospital stay in the two groups were compared.Results:After treatment,curative effect of combination group was significantly better than that of NIPPV group(P<0.05).Compared with NIPPV group,length of hospital stay and weaning time were shortened in combination group(P<0.05).After treatment,oxygenation index and LVEF were significantly increased in both groups(P<0.05),especially in combination group(P<0.05).After treatment,NT-proBNP and LVEDD were significantly decreased in both groups(P<0.05),especially in combination group(P<0.05).After treatment,24h urine volume was significantly increased in both groups(P<0.05),especially in combination group(P<0.05).Conclusion:Curative effect of NIPPV assisted with rhBNP is good in patients with ALHF,which can effectively improve blood oxygen content and left ventricular pumping function,and promote recovery of patients.

关 键 词：无创正压通气 急性左心衰竭 重组人脑利钠肽 氧合指数 左室射血分数 

分 类 号：R541.6[医药卫生—心血管疾病]